ArticleHuman immunology2010
Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.
Article in Human immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- T(H)2-like chemokine patterns correlate with disease severity in patients with recurrent respiratory papillomatosis.Molecular medicine (Cambridge, Mass.) · 2012Trial
- Clonal expansion and phenotypic alterations of TCR Vβ3Journal of virology · 2026Article
- The Role of Killer Ig-like Receptors in Diseases from A to Z.International journal of molecular sciences · 2025Review
- The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to severe COVID-19 in the Iranian population.BMC immunology · 2024Article
- Review
- Restricted Recruitment of NK Cells with Impaired Function Is Caused by HPV-Driven Immunosuppressive Microenvironment of Papillomas in Aggressive Juvenile-Onset Recurrent Respiratory Papillomatosis Patients.Journal of virology · 2022Article
- Human Papillomavirus Infection during Pregnancy and Childhood: A Comprehensive Review.Microorganisms · 2022Review
- Oropharyngeal tumor cells induce COX-2 expression in peripheral blood monocytes by secretion of IL-1α.Frontiers in immunology · 2022Article
- How Enhancing Immunity to Low-Risk HPV Could Cure Recurrent Respiratory Papillomatosis.The Laryngoscope · 2021Review
- Maternal natural killer cells at the intersection between reproduction and mucosal immunity.Mucosal immunology · 2021Review
- Histological Severity Risk Factors Identification in Juvenile-Onset Recurrent Respiratory Papillomatosis: How Immunohistochemistry and AI Algorithms Can Help?Frontiers in oncology · 2021Article
- The Role of HLA and KIR Immunogenetics in BK Virus Infection after Kidney Transplantation.Viruses · 2020Review
- Article
- Immunological tolerance of low-risk HPV in recurrent respiratory papillomatosis.Clinical and experimental immunology · 2020Review
- Altered Monocyte and Langerhans Cell Innate Immunity in Patients With Recurrent Respiratory Papillomatosis (RRP).Frontiers in immunology · 2020Article
- The Host-Microbe Interplay in Human Papillomavirus-Induced Carcinogenesis.Microorganisms · 2019Review
- The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface.Frontiers in immunology · 2019Review
- The impact of KIR-HLA genotype on hepatitis B virus clearance in Iranian infected individuals.Medical microbiology and immunology · 2017Article
- Lymphocyte profile and cytokine mRNA expression in peripheral blood mononuclear cells of patients with recurrent respiratory papillomatosis suggest dysregulated cytokine mRNA response and impaired cytotoxic capacity.Immunity, inflammation and disease · 2017Article
- Missing or altered self: human NK cell receptors that recognize HLA-C.Immunogenetics · 2017Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
The polymorphic killer cell immunoglobulin-like receptors (KIR) control natural killer (NK) cell response against viral infection and tumor transformation. Here we investigated if select KIR genes are associated with recurrent respiratory papillomatosis (RRP), a rare disease of the larynx and upper airway caused by human papillomaviruses (HPV)-6/11. DNA from 66 RRP patients and 195 healthy controls were characterized for KIR and HLA gene polymorphism. Patients lacking activating KIR genes 3DS1 and 2DS1 were more common in severe RRP compared with mild-moderate RRP (78.8% vs 48.5%, p = 0.019). Further, patients carrying any of the known susceptible HLA-DRB1/DQB1 alleles were more frequently negative for KIR3DS1 (p = 0.006), KIR2DS1 (p = 0.003) or KIR2DS5 (p = 0.004) compared with controls carrying any of these HLA allotypes. Nearly 80% of the patients with severe disease were missing the protective HLA-DQB1*0602 allele as well as both KIR3DS1 and KIR2DS1 genes. Phenotyping of papilloma-infiltrating mononuclear-cells revealed an elevated numbers of NK cells and CD57(+)CD4(+) T cells in KIR3DS1(-)KIR2DS1(-) patients compared with patients carrying either one or both of these KIRs. Our data suggest that NK cells expressing activating receptors KIR3DS1 and KIR2DS1 may be necessary to trigger an effective early immune response against HPV-infected targets to establish resistance to RRP development.
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Registered trials
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