Evidence map›Paper›PMID 19861069›Full record

ArticleEmerging infectious diseases2009

Poor clinical sensitivity of rapid antigen test for influenza A pandemic (H1N1) 2009 virus.

Jan Felix Drexler, Angelika Helmer, Heike Kirberg, Ulrike Reber, Marcus Panning, Marcel Müller, Katja Höfling, Bertfried Matz, Christian Drosten, Anna Maria Eis-Hübinger

Abstract readEvaluation Study
In one paragraph

Article in Emerging infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Performance of rapid influenza H1N1 diagnostic tests: a meta-analysis.Influenza and other respiratory viruses · 2012
    Pooled it
  4. Pooled it
  5. Causes of fever in primary care in Southeast Asia and the performance of C-reactive protein in discriminating bacterial from viral pathogens.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. CRISPR-Based Assays for Point-of-Need Detection and Subtyping of Influenza.The Journal of molecular diagnostics : JMD · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Optofluidic multiplex detection of single SARS-CoV-2 and influenza A antigens using a novel bright fluorescent probe assay.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Antigen tests for COVID-19.Biophysics and physicobiology · 2021
    Article
  18. Article
  19. Article
  20. Community-acquired respiratory viruses in solid organ transplant.Current opinion in organ transplantation · 2019
    Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jan Felix DrexlerInstitute of Virology, Bonn, Germany.
Angelika Helmer
Heike Kirberg
Ulrike Reber
Marcus Panning
Marcel Müller
Katja Höfling
Bertfried Matz
Christian Drosten
Anna Maria Eis-Hübinger

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza A pandemic (H1N1) 2009 virus RNA was detected by reverse transcription-PCR in 144 clinical samples from Bonn, Germany. A common rapid antigen-based test detected the virus in only 11.1% of these samples. The paramount feature of rapid test-positive samples was high virus concentration. Antigen-based rapid tests appear unsuitable for virologic diagnostics in the current pandemic.

Indexed as

Disease OutbreaksAdolescentAdultAntigens, ViralChildChild, PreschoolFalse Negative ReactionsHumansInfantInfluenza A Virus, H1N1 SubtypeInfluenza, HumanPolymerase Chain ReactionSensitivity and SpecificitySerologic TestsYoung AdultAntigens, Viral

Identifiers

PMID19861069
PMCPMC2866420

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.