ArticleBehavioral and brain functions : BBF2009
Mercury exposure, nutritional deficiencies and metabolic disruptions may affect learning in children.
Article in Behavioral and brain functions : BBF, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 90 citations in OpenAlex.
- Revealing the potential of biogenic carbon dot-based nanosensor for the high-throughput detection of carcinogenic HgMikrochimica acta · 2025Article
- Biomarkers for tracking metabolic changes pre-post nutritional epigenetics diet/intervention to prevent autism and attention deficit/hyperactivity disorders in children.World journal of experimental medicine · 2025Review
- Heavy Metal and Thiol/Disulfide in Children with Attention-Deficit and Hyperactivity Disorder.Psychiatry and clinical psychopharmacology · 2024Article
- Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder.World journal of psychiatry · 2024Article
- Higher rates of autism and attention deficit/hyperactivity disorder in American children: Are food quality issues impacting epigenetic inheritance?World journal of clinical pediatrics · 2023Review
- A Review of the Association of Blue Food Coloring With Attention Deficit Hyperactivity Disorder Symptoms in Children.Cureus · 2022Review
- Investigation of Protein Biomarkers and Oxidative Stress in Pinirampus pirinampu Exposed to Mercury Species from the Madeira River, Amazon-Brazil.Biological trace element research · 2022Article
- Connecting inorganic mercury and lead measurements in blood to dietary sources of exposure that may impact child development.World journal of methodology · 2021Review
- Mercury Toxicity and Detection Using Chromo-Fluorogenic Chemosensors.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Oxidative Stress Levels Induced by Mercury Exposure in Amazon Juvenile Populations in Brazil.International journal of environmental research and public health · 2019Article
- Mercury leads to abnormal red blood cell adhesion to laminin mediated by membrane sulfatides.Biochimica et biophysica acta. Biomembranes · 2019Article
- A comparison of blood metal levels in autism spectrum disorder and unaffected children in Shenzhen of China and factors involved in bioaccumulation of metals.Environmental science and pollution research international · 2018Article
- Rationale for Dietary Antioxidant Treatment of ADHD.Nutrients · 2018Review
- Correction to: Mercury exposure, nutritional deficiencies and metabolic disruptions may affect learning in children.Behavioral and brain functions : BBF · 2018Article
- The Relationship between Zinc Levels and Autism: A Systematic Review and Meta-analysis.Iranian journal of child neurology · 2016Review
- Effects of trace metal profiles characteristic for autism on synapses in cultured neurons.Neural plasticity · 2015Article
- Blood inorganic mercury is directly associated with glucose levels in the human population and may be linked to processed food intake.Integrative molecular medicine · 2015Article
- A comparison of temporal trends in United States autism prevalence to trends in suspected environmental factors.Environmental health : a global access science source · 2014Article
- Differential network analyses of Alzheimer's disease identify early events in Alzheimer's disease pathology.International journal of Alzheimer's disease · 2014Article
- Assessment of infantile mineral imbalances in autism spectrum disorders (ASDs).International journal of environmental research and public health · 2013Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among dietary factors, learning and behavior are influenced not only by nutrients, but also by exposure to toxic food contaminants such as mercury that can disrupt metabolic processes and alter neuronal plasticity. Neurons lacking in plasticity are a factor in neurodevelopmental disorders such as autism and mental retardation. Essential nutrients help maintain normal neuronal plasticity. Nutritional deficiencies, including deficiencies in the long chain polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid, the amino acid methionine, and the trace minerals zinc and selenium, have been shown to influence neuronal function and produce defects in neuronal plasticity, as well as impact behavior in children with attention deficit hyperactivity disorder. Nutritional deficiencies and mercury exposure have been shown to alter neuronal function and increase oxidative stress among children with autism. These dietary factors may be directly related to the development of behavior disorders and learning disabilities. Mercury, either individually or in concert with other factors, may be harmful if ingested in above average amounts or by sensitive individuals. High fructose corn syrup has been shown to contain trace amounts of mercury as a result of some manufacturing processes, and its consumption can also lead to zinc loss. Consumption of certain artificial food color additives has also been shown to lead to zinc deficiency. Dietary zinc is essential for maintaining the metabolic processes required for mercury elimination. Since high fructose corn syrup and artificial food color additives are common ingredients in many foodstuffs, their consumption should be considered in those individuals with nutritional deficits such as zinc deficiency or who are allergic or sensitive to the effects of mercury or unable to effectively metabolize and eliminate it from the body.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.