Trial reportClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2009
The interaction of glutathione S-transferase M1-null variants with tobacco smoke exposure and the development of childhood asthma.
Trial report in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review.Current allergy and asthma reports · 2018Pooled it
- Passive Tobacco Smoke Exposure, Oxidative Stress and Pediatric Allergic and Obstructive Respiratory Diseases: A Systematic Review and a "Second Oxidative Hit" Hypothesis.Antioxidants (Basel, Switzerland) · 2026Review
- Article
- Copy Number Variation in Asthma: An Integrative Review.Clinical reviews in allergy & immunology · 2025Review
- Predicting Young Adult Tobacco, Drug and Alcohol Use Among Participants in the CAMP Trial.Journal of clinical psychology in medical settings · 2022Article
- Genetics of Asthma and Allergic Diseases.Handbook of experimental pharmacology · 2022Article
- Interactions between glutathione S-transferase genes and household air pollution on asthma and lung function.Frontiers in molecular biosciences · 2022Review
- Second-hand smoke and NFE2L2 genotype interaction increases paediatric asthma risk and severity.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma.Frontiers in pediatrics · 2019Review
- Paternal Tobacco Smoke Correlated to Offspring Asthma and Prenatal Epigenetic Programming.Frontiers in genetics · 2019Article
- Air pollutants and early origins of respiratory diseases.Chronic diseases and translational medicine · 2018Article
- Outdoor air pollution and asthma.Lancet (London, England) · 2014Review
- Glutathione S transferase theta1 and mu1 gene polymorphisms and phenotypic expression of asthma in Egyptian children: a case-control study.Italian journal of pediatrics · 2014Article
- Gender-dependent effect of GSTM1 genotype on childhood asthma associated with prenatal tobacco smoke exposure.BioMed research international · 2014Article
- Selection of genes for gene-environment interaction studies: a candidate pathway-based strategy using asthma as an example.Environmental health : a global access science source · 2013Article
- Copy number variation prevalence in known asthma genes and their impact on asthma susceptibility.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2013Article
- Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities.Antioxidants & redox signaling · 2012Review
- Different implications of paternal and maternal atopy for perinatal IgE production and asthma development.Clinical & developmental immunology · 2012Review
- Perinatal gene-gene and gene-environment interactions on IgE production and asthma development.Clinical & developmental immunology · 2012Review
- Unravelling gene-by-environment effects in asthma and allergy: the glutathione pathway as an early success story.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe glutathione S-transferase M1 (GSTM1)-null variant is a common copy number variant associated with adverse pulmonary outcomes, including asthma and airflow obstruction, with evidence of important gene-by-environment interactions with exposures to oxidative stress.
objectiveTo explore the joint interactive effects of GSTM1 copy number and tobacco smoke exposure on the development of asthma and asthma-related phenotypes in a family-based cohort of childhood asthmatics.
methodsWe performed quantitative PCR-based genotyping for GSTM1 copy number in children of self-reported white ancestry with mild to moderate asthma in the Childhood Asthma Management Program. Questionnaire data regarding intrauterine (IUS) and post-natal, longitudinal smoke exposure were available. We performed both family-based and population-based tests of association for the interaction between GSTM1 copy number and tobacco smoke exposure with asthma and asthma-related phenotypes.
resultsAssociations of GSTM1-null variants with asthma (P=0.03), younger age of asthma symptom onset (P=0.03), and greater airflow obstruction (reduced forced expiratory volume in 1 s / forced vital capacity, P=0.01) were observed among the 50 children (10% of the cohort) with exposure to IUS. In contrast, no associations were observed between GSTM1-null variants and asthma-related phenotypes among children without IUS exposure. Presence of at least one copy of GSTM1 conferred protection.
conclusionThese findings support an important gene-by-environment interaction between two common factors: increased risk of asthma and asthma-related phenotypes conferred by GSTM1-null homozygosity in children is restricted to those with a history of IUS exposure.
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