ArticleAlcoholism, clinical and experimental research2010
Initial evidence of an association between OPRM1 and adolescent alcohol misuse.
Article in Alcoholism, clinical and experimental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies.BMC medical genetics · 2017Pooled it
- The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist GSK1521498 in healthy subjects.Journal of clinical pharmacology · 2013Trial
- Parent and Adolescent Reports of Parental Monitoring and Sources of Parental Knowledge are Linked to Cannabis Use and Symptom Development in Adolescents.Cannabis (Albuquerque, N.M.) · 2022Article
- Mu opioid receptor gene variant modulates subjective response to smoked cannabis.American journal of translational research · 2022Article
- Effects of OPRM1 and DRD2 on brain structure in drug-naïve adolescents: Genetic and neural vulnerabilities to substance use.Psychopharmacology · 2022Article
- Genetic Vulnerability to Opioid Addiction.Cold Spring Harbor perspectives in medicine · 2021Review
- Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons.Molecular psychiatry · 2020Article
- Genetic Polymorphisms onFrontiers in psychiatry · 2020Article
- Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population.CNS neuroscience & therapeutics · 2020Article
- The Impact of Genes on Adolescent Substance Use: A Developmental Perspective.Current addiction reports · 2019Article
- Bi-directional Acceleration of Alcohol Use and Opioid Use Disorder.Journal of drug and alcohol research · 2019Article
- Synaptic Regulation by OPRM1 Variants in Reward Neurocircuitry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Robust age, but limited sex, differences in mu-opioid receptors in the rat brain: relevance for reward and drug-seeking behaviors in juveniles.Brain structure & function · 2018Article
- The frequency ofAnnals of general psychiatry · 2018Article
- Genetic influences on adolescent behavior.Neuroscience and biobehavioral reviews · 2016Review
- Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults.Addiction biology · 2016Article
- Article
- Pharmacogenetics of OPRM1.Pharmacology, biochemistry, and behavior · 2014Review
- Neurobiology of adolescent substance use and addictive behaviors: treatment implications.Adolescent medicine: state of the art reviews · 2014Review
- Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents.Alcoholism, clinical and experimental research · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundConsiderable research efforts have attempted to identify genes associated with alcoholism among adults, yet few studies have examined adolescents. Identifying genes associated with alcohol misuse in youth is important given that the relative contribution of genetic and environmental influences on alcoholism varies across development. The purpose of this study was to examine the association between a polymorphism of the mu-opioid receptor gene (OPRM1) and alcohol misuse in a sample of youth and to test whether heightened sensitivity to the reinforcing effects of alcohol mediated this relationship.
methodsAdolescents (n = 187; mean age = 15.4 years; 47.6% female) were genotyped for A118G (rs1799971), a single-nucleotide polymorphism (SNP) of the OPRM1 gene, and assessed for alcohol use disorder (AUD) diagnoses and other psychopathology. Alcohol misuse was also measured continuously to maximize detection of drinking problems in youth. Drinking motives were used to capture the extent to which youth consumed alcohol to enhance positive affect.
resultsAUD groups differed significantly in terms of allelic distributions of the A118G SNP, such that 51.9% of youth with an AUD carried at least one copy of the G allele compared to 16.3% of non-AUD controls. Those who carried the G allele endorsed drinking to enhance positive affect more strongly than those who were homozygous for the A allele and drinking to enhance positive affect mediated the association between OPRM1 and alcohol-related problems.
conclusionsThese data build on findings from adult studies and provide the first evidence that a polymorphism of the OPRM1 receptor gene is associated with the development of early-onset alcohol-related problems during adolescence, in part, by heightening sensitivity to the reinforcing effects of alcohol.
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Registered trials
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