ReviewInfectious disorders drug targets2009
Structural genomics and drug discovery for infectious diseases.
Review in Infectious disorders drug targets, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Structural and biophysical aspects of l-asparaginases: a growing family with amazing diversity.IUCrJ · 2021Review
- Developing a macromolecular crystallography driven CURE.Structural dynamics (Melville, N.Y.) · 2021Article
- Synchrotron Radiation as a Tool for Macromolecular X-Ray Crystallography: a XXI Century Perspective.Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms · 2021Article
- Article
- Structural and immunological characterization ofBioscience reports · 2018Article
- Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing.PLoS pathogens · 2018Article
- CSGID Solves Structures and Identifies Phenotypes for Five Enzymes inFrontiers in cellular and infection microbiology · 2018Article
- Survey of Predictors of Propensity for Protein Production and Crystallization with Application to Predict Resolution of Crystal Structures.Current protein & peptide science · 2018Article
- Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus.Antiviral research · 2017Article
- Databases, Repositories, and Other Data Resources in Structural Biology.Methods in molecular biology (Clifton, N.J.) · 2017Review
- Crystal Structures of the SpoIID Lytic Transglycosylases Essential for Bacterial Sporulation.The Journal of biological chemistry · 2016Article
- Increasing the structural coverage of tuberculosis drug targets.Tuberculosis (Edinburgh, Scotland) · 2015Article
- X-ray crystallography over the past decade for novel drug discovery - where are we heading next?Expert opinion on drug discovery · 2015Review
- PATRIC, the bacterial bioinformatics database and analysis resource.Nucleic acids research · 2014Article
- Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus.Journal of structural and functional genomics · 2013Article
- Structure of anabolic ornithine carbamoyltransferase from Campylobacter jejuni at 2.7 Å resolution.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
- Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
- Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni.Journal of structural and functional genomics · 2012Article
- Structural genomics of infectious disease drug targets: the SSGCID.Acta crystallographica. Section F, Structural biology and crystallization communications · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The application of structural genomics methods and approaches to proteins from organisms causing infectious diseases is making available the three dimensional structures of many proteins that are potential drug targets and laying the groundwork for structure aided drug discovery efforts. There are a number of structural genomics projects with a focus on pathogens that have been initiated worldwide. The Center for Structural Genomics of Infectious Diseases (CSGID) was recently established to apply state-of-the-art high throughput structural biology technologies to the characterization of proteins from the National Institute for Allergy and Infectious Diseases (NIAID) category A-C pathogens and organisms causing emerging, or re-emerging infectious diseases. The target selection process emphasizes potential biomedical benefits. Selected proteins include known drug targets and their homologs, essential enzymes, virulence factors and vaccine candidates. The Center also provides a structure determination service for the infectious disease scientific community. The ultimate goal is to generate a library of structures that are available to the scientific community and can serve as a starting point for further research and structure aided drug discovery for infectious diseases. To achieve this goal, the CSGID will determine protein crystal structures of 400 proteins and protein-ligand complexes using proven, rapid, highly integrated, and cost-effective methods for such determination, primarily by X-ray crystallography. High throughput crystallographic structure determination is greatly aided by frequent, convenient access to high-performance beamlines at third-generation synchrotron X-ray sources.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.