Evidence map›Paper›PMID 19860577›Full record

GuidelineThyroid : official journal of the American Thyroid Association2009

Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer.

American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, David S Cooper, Gerard M Doherty, Bryan R Haugen, Bryan R Hauger, Richard T Kloos, Stephanie L Lee, Susan J Mandel, Ernest L Mazzaferri, Bryan McIver and 5 more

Erratum issued 4 registry-linked trialsOpen access · greenAbstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Thyroid : official journal of the American Thyroid Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 4 registered trials, which are not on this map. Cited by 2,346 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2,346citing papers in PubMed, 13 pooled it
247.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04298684 phase4unknown statusstarted 2021, after this paper: background citation

Efficacy of Metformin Versus Sitagliptin on Benign Thyroid Nodules Size in Type 2 Diabetes: a 2-years Prospective Multicentric Study

Ran2021Enrolled90Registered outcomes9Posted comparisons0ConditionsDiabetes Mellitus, Type 2, Thyroid Nodule (Benign)ArmsMetformin, Sitagliptin
PMID 26154837PMID 27987248PMID 15562188PMID 9839117PMID 3899825PMID 30233494PMID 29858981PMID 29158735PMID 28196954PMID 20578900PMID 19633072PMID 19320560other papers from this trial
Open the trial in the graph
NCT01704586 naactive not recruitingnot on this mapstarted 2015, after this paper: background citation

Clinical Evaluation of a I-124 PET/CT Based Remnant Radioiodine Ablation Decision Concept in Differentiated Thyroid Cancer Using PROBE Design

TypeinterventionalSponsorUniversity of WuerzburgRan2015 to 2031Enrolled340ConditionsDifferentiated Thyroid CarcinomaArmsRadioiodine I-131, I-124
NCT01757834 naunknown statusnot on this mapstarted 2012, after this paper: background citation

Efficacy of Shear Wave Ultrasound Elastography in Noninvasive Diagnosis of Thyroid Nodules

TypeinterventionalSponsorUniversity of WashingtonRan2012 to 2015Enrolled175ConditionsThyroid NoduleArmsSWUS Elastography
NCT06161467 unknown statusnot on this mapstarted 2023, after this paper: background citation

Transcutaneous Laryngeal Ultrasoungraphy (TLUS) as an Alternative to Direct Flexible Laryngoscopy (DFL) in Assessment of Vocal Cords Appearance in Patients Underwent Thyroid Surgery

TypeobservationalSponsorAssiut UniversityRan2023 to 2025Enrolled46ConditionsUltrasound Therapy, ComplicationsArmsUltrasound devices
3 · Its place in the literature

Who cites it

2,346 citing papers in PubMed, 13 syntheses or guidelines pooled it, 6,725 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Guideline
  8. Pooled it
  9. Completion Thyroidectomy Trends and Rates: A Systematic Review and Meta-Analysis.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025
    Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Trial
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

2,286 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 13 institutions in 3 countries.

American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerThe Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. dscooper@jhmi.edu
David S Cooper
Gerard M Doherty
Bryan R Haugen
Bryan R Hauger
Richard T Kloos
Stephanie L Lee
Susan J Mandel
Ernest L Mazzaferri
Bryan McIver
Furio Pacini
Martin Schlumberger
Steven I Sherman
David L Steward
R Michael Tuttle
Florida College · USInstitut Gustave Roussy · FRJohns Hopkins Medicine · USMayo Clinic · USMemorial Sloan Kettering Cancer Center · USThe Ohio State University · USThe University of Texas MD Anderson Cancer Center · USUniversity Medical Center · USUniversity of Cincinnati · USUniversity of Colorado Health · USUniversity of Michigan–Ann Arbor · USUniversity of Pennsylvania · USUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the publication of the American Thyroid Association's guidelines for the management of these disorders was published in 2006, a large amount of new information has become available, prompting a revision of the guidelines.

methodsRelevant articles through December 2008 were reviewed by the task force and categorized by topic and level of evidence according to a modified schema used by the United States Preventative Services Task Force.

resultsThe revised guidelines for the management of thyroid nodules include recommendations regarding initial evaluation, clinical and ultrasound criteria for fine-needle aspiration biopsy, interpretation of fine-needle aspiration biopsy results, and management of benign thyroid nodules. Recommendations regarding the initial management of thyroid cancer include those relating to optimal surgical management, radioiodine remnant ablation, and suppression therapy using levothyroxine. Recommendations related to long-term management of differentiated thyroid cancer include those related to surveillance for recurrent disease using ultrasound and serum thyroglobulin as well as those related to management of recurrent and metastatic disease.

conclusionsWe created evidence-based recommendations in response to our appointment as an independent task force by the American Thyroid Association to assist in the clinical management of patients with thyroid nodules and differentiated thyroid cancer. They represent, in our opinion, contemporary optimal care for patients with these disorders.

Indexed as

AdenocarcinomaBiopsy, Fine-NeedleCarcinoma, PapillaryCombined Modality TherapyDiagnosis, DifferentialDisease ProgressionHumansIodine RadioisotopesLymph NodesNeckPhysical ExaminationPrognosisThyroid GlandThyroid NeoplasmsTreatment OutcomeUnited StatesIodine Radioisotopes

Identifiers

PMID19860577
OpenAlexW2116542352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.