ArticleThe Journal of infectious diseases2009
Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivo.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Acyloxyacyl Hydrolase Protects against Kidney Injury via Inhibition of Tubular CD74-Macrophage Crosstalk.International journal of biological sciences · 2024Article
- Acyloxyacyl hydrolase deficiency induces chronic inflammation and bone loss in male mice.Journal of molecular medicine (Berlin, Germany) · 2022Article
- Transmission distortion and genetic incompatibilities between alleles in a multigenerational mouse advanced intercross line.Genetics · 2022Article
- A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice.eLife · 2021Article
- Article
- Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery.The Journal of biological chemistry · 2020Review
- Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock.EMBO reports · 2020Article
- Myeloid Cells Enriched for a Dendritic Cell Population From People Living With HIV Have Altered Gene Expression Not Restored by Antiretroviral Therapy.Frontiers in immunology · 2020Article
- Acyloxyacyl hydrolase modulates pelvic pain severity.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Crystal structure of the mammalian lipopolysaccharide detoxifier.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury.PLoS pathogens · 2017Article
- Alkaline phosphatase protects lipopolysaccharide-induced early pregnancy defects in mice.PloS one · 2015Article
- Novel insights in preventing Gram-negative bacterial infection in cirrhotic patients: review on the effects of GM-CSF in maintaining homeostasis of the immune system.Hepatology international · 2015Review
- Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo.Blood · 2014Article
- One airway: Biomarkers of protection from upper and lower airway injury after World Trade Center exposure.Respiratory medicine · 2014Article
- Persistently active microbial molecules prolong innate immune tolerance in vivo.PLoS pathogens · 2013Article
- Genetics of chronic rhinosinusitis: state of the field and directions forward.The Journal of allergy and clinical immunology · 2013Review
- Article
- Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Although recognition of lipopolysaccharide (LPS) by the myeloid differentiation factor 2-Toll-like receptor 4 complex is important for triggering protective inflammatory responses in animals, terminating many of these responses requires LPS inactivation by a host lipase, acyloxyacyl hydrolase (AOAH). To test whether endogenously produced recombinant AOAH can modulate responses to LPS and gram-negative bacteria, we engineered transgenic mice that overexpress AOAH in dendritic cells and macrophages, cell types that normally produce it. Transgenic mice deacylated LPS more rapidly than did wild-type controls. They also were protected from LPS-induced hepatosplenomegaly, recovered more quickly from LPS-induced weight loss, and were more likely to survive when challenged with live Escherichia coli. Constitutive overexpression of AOAH in vivo hastened recovery from LPS exposure without interfering with the normal acute inflammatory response to this important microbial signal molecule. Our results suggest that the extent to which macrophages and dendritic cells produce AOAH may influence the outcome of many gram-negative bacterial diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.