ArticleThe Journal of cell biology1991
Contrasting expression patterns of three members of the myc family of protooncogenes in the developing and adult mouse kidney.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 93 citations in OpenAlex.
- Immunomodulation therapy offers new molecular strategies to treat UTI.Nature reviews. Urology · 2022Review
- Molecular determinants of disease severity in urinary tract infection.Nature reviews. Urology · 2021Review
- A bacterial protease depletes c-MYC and increases survival in mouse models of bladder and colon cancer.Nature biotechnology · 2021Article
- Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system.Developmental biology · 2020Article
- MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells.Oncotarget · 2016Article
- Kidney Regeneration: Lessons from Development.Current pathobiology reports · 2015Article
- Defining and redefining the nephron progenitor population.Pediatric nephrology (Berlin, Germany) · 2011Review
- Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3.Molecular and cellular biology · 2010Article
- The dysregulated glomerular cell growth in Denys-Drash syndrome.Virchows Archiv : an international journal of pathology · 2004Article
- Article
- Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia.Developmental biology · 2002Article
- N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.Genes & development · 2000Article
- RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2.Molecular and cellular biology · 1998Article
- The development of the kidney.Current topics in developmental biology · 1998Review
- Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression.The American journal of pathology · 1998Article
- Analysis of WT1 gene expression during mouse nephrogenesis in organ culture.In vitro cellular & developmental biology. Animal · 1996Article
- The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations.The Journal of clinical investigation · 1996Article
- Expression and activity of L-Myc in normal mouse development.Molecular and cellular biology · 1996Article
- Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo.The EMBO journal · 1995Article
- A putative Wilms tumor-secreted growth factor activity required for primary culture of human nephroblasts.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The myc family of protooncogenes encode similar but distinct nuclear proteins. Since N-myc, c-myc, and L-myc have been found to be expressed in the newborn kidney, we studied their expression during murine kidney development. By organ culture studies and in situ hybridization of tissue sections, we found that each of the three members of the myc gene family shows a remarkably distinct expression pattern during kidney development. It is known that mesenchymal stem cells of the embryonic kidney convert into epithelium if properly induced. We demonstrate the N-myc expression increases during the first 24 h of in vitro culture as an early response to induction. Moreover, the upregulation was transient and expression levels were already low during the first stages of overt epithelial cell polarization. In contrast, neither c-myc nor L-myc were upregulated by induction of epithelial differentiation. c-myc was expressed in the uninduced mesenchyme but subsequently became restricted to the newly formed epithelium and was not expressed in the surrounding loose mesenchyme. At onset of terminal differentiation c-myc expression was turned off also from the epithelial tubules. We conclude that N-myc is a marker for induction and early epithelial differentiation states. That the undifferentiated mesenchyme, unlike stromal cells of later developmental stages, express c-myc demonstrates that the undifferentiated mesenchymal stem cells are distinct from the stromal cells. The most astonishing finding, however, was the high level of L-myc mRNA in the ureter, ureter-derived renal pelvis, papilla, and collecting ducts. In the ureter, expression increased, rather than decreased, with advancing maturation and was highest in adult tissue. Our results suggest that each of the three members of the myc gene family are involved in quite disparate differentiation processes, even within one tissue.
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