ArticleJournal of neuroscience research2010
Axon responses of embryonic stem cell-derived dopaminergic neurons to semaphorins 3A and 3C.
Article in Journal of neuroscience research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Nigral transcriptomic profiles in Engrailed-1 hemizygous mouse models of Parkinson's disease reveal upregulation of oxidative phosphorylation-related genes associated with delayed dopaminergic neurodegeneration.Frontiers in aging neuroscience · 2024Article
- Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM ThroughThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Semaphorin 3C as a Therapeutic Target in Prostate and Other Cancers.International journal of molecular sciences · 2019Review
- Cytotoxic Effects of Environmental Toxins on Human Glial Cells.Neurotoxicity research · 2017Article
- Semaphorin 3C Released from a Biocompatible Hydrogel Guides and Promotes Axonal Growth of Rodent and Human Dopaminergic Neurons.Tissue engineering. Part A · 2016Article
- Hydrogels as scaffolds and delivery systems to enhance axonal regeneration after injuries.Frontiers in cellular neuroscience · 2015Review
- Canonical BMP-Smad signalling promotes neurite growth in rat midbrain dopaminergic neurons.Neuromolecular medicine · 2014Article
- Ascending midbrain dopaminergic axons require descending GAD65 axon fascicles for normal pathfinding.Frontiers in neuroanatomy · 2014Article
- Recovery from experimental parkinsonism by semaphorin-guided axonal growth of grafted dopamine neurons.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- A network view on Parkinson's disease.Computational and structural biotechnology journal · 2013Article
- Dopaminergic axon guidance: which makes what?Frontiers in cellular neuroscience · 2012Article
- Delivery of chemotropic proteins and improvement of dopaminergic neuron outgrowth through a thixotropic hybrid nano-gel.Journal of materials science. Materials in medicine · 2011Article
- Cell Therapy From Bench to Bedside Translation in CNS Neurorestoratology Era.Cell medicine · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Class 3 Semaphorins are a subfamily of chemotropic molecules implicated in the projection of dopaminergic neurons from the ventral mesencephalon and in the formation of the nigrostriatal pathway (NSP) during embryonic development. In humans, loss of mesencephalic dopaminergic neurons leads to Parkinson's disease (PD). Cell replacement therapy with dopaminergic neurons generated from embryonic stem cells (ES-TH(+)) is being actively explored in models of PD. Among several requisites for this approach to work are adequate reconstruction of the NSP and correct innervation of normal striatal targets by dopaminergic axons. In this work, we characterized the response of ES-TH(+) neurons to semaphorins 3A, 3C, and 3F and compared it with that of tyrosine hidroxylase-positive neurons (TH(+)) obtained from embryonic ventral mesencephalon (VM-TH(+)). We observed that similar proportions of ES-TH(+) and VM-TH(+) neurons express semaphorin receptors neuropilins 1 and 2. Furthermore, the axons of both populations responded very similarly to semaphorin exposure: semaphorin 3A increased axon length, and semaphorin 3C attracted axons and increased their length. These effects were mediated by neuropilins, insofar as addition of blocking antibodies against these proteins reduced the effects on axonal growth and attraction, and only TH(+) axons expressing neuropilins responded to the semaphorins analyzed. The observations reported here show phenotypic similarities between VM-TH(+) and ES-TH(+) neurons and suggest that semaphorins 3A and 3C could be employed to guide axons of grafted ES-TH(+) in therapeutic protocols for PD.
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Registered trials
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