ArticleCerebellum (London, England)2010
Cerebellar lingula size and experiential risk factors associated with high levels of alcohol and drug use in young adults.
Article in Cerebellum (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Longitudinal patterns of threat- and deprivation-based childhood adversity and their impact on adolescent drinking, smoking, and depression.Child abuse & neglect · 2026Article
- The Associations of Adverse Childhood Experiences (ACEs) With Substance Use in Young Adults: A Systematic Review.Substance abuse : research and treatment · 2023Review
- The mediating role of impulsivity in the associations between child maltreatment types and past month substance use.Child abuse & neglect · 2022Article
- Cerebellar Morphometry and Cognition in the Context of Chronic Alcohol Consumption and Cigarette Smoking.Alcoholism, clinical and experimental research · 2020Article
- Structural and Functional Brain Abnormalities Associated With Exposure to Different Childhood Trauma Subtypes: A Systematic Review of Neuroimaging Findings.Frontiers in psychiatry · 2018Article
- Alcohol-related cerebellar degeneration: not all down to toxicity?Cerebellum & ataxias · 2016Article
- Reduced cerebellar brain activity during reward processing in adolescent binge drinkers.Developmental cognitive neuroscience · 2015Article
- Childhood Maltreatment, Depression, and Suicidal Ideation: Critical Importance of Parental and Peer Emotional Abuse during Developmental Sensitive Periods in Males and Females.Frontiers in psychiatry · 2015Article
- Magnetic resonance imaging biomarkers in patients with progressive ataxia: current status and future direction.Cerebellum (London, England) · 2013Review
- Witnessing violence toward siblings: an understudied but potent form of early adversity.PloS one · 2011Article
- Hurtful words: association of exposure to peer verbal abuse with elevated psychiatric symptom scores and corpus callosum abnormalities.The American journal of psychiatry · 2010Article
- Harsh corporal punishment is associated with increased T2 relaxation time in dopamine-rich regions.NeuroImage · 2010Article
- Cerebellar lingula thickness as a novel risk factor for alcohol and drug abuse.Cerebellum (London, England) · 2010Article
- Adverse Childhood Experiences and the Presence of Cancer Risk Factors in Adulthood: A Scoping Review of the Literature From 2005 to 2015.Journal of pediatric nursingArticle
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4 authors at 1 institution in 1 country.
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Abstract
Previous studies have reported cerebellar abnormalities or static ataxia associated with risk for chronic use of alcohol and drugs. Adverse childhood experience is another strong risk factor for later substance abuse. We therefore sought to ascertain the relationship between morphological phenotypes of the lingula (lobule I) of the anterior cerebellar vermis, and exposure to emotional (EM) versus physical (PM) maltreatment, on the degree of ongoing alcohol or drug use. The study design consisted of a cross-sectional in vivo neuroimaging study, utilizing retrospective assessment of maltreatment history and self-reports of alcohol and substance use. Study participants were 153 subjects (54 M/99F, 21.9 +/- 2.2 years) selected for imaging from a database of 1,402 community participants 18-25 years of age, who completed a detailed online screening instrument and met rigorous inclusion/exclusion criteria. Subjects were exposed to only physical abuse or harsh corporal punishment (HCP; PM group, n = 37) and parental verbal abuse and/or witnessing domestic violence (EM group, n = 58) or had no history of maltreatment or axis I disorders (n = 58). The main outcome measures consisted of the gray matter volume of lobule I as measured by manual tracing, number and type of alcoholic beverages consumed during a drinking session, number of sessions per month, and monthly drug use, along with family history of drug and alcohol abuse. Lingula thickness was not attenuated by alcohol use or maltreatment history. However, increased lingula thickness was associated with greater consumption of drugs and hard liquor, particularly in physically maltreated subjects who consumed 2.5- and 2.7-fold more alcohol and used drugs 6.1- and 7.8-fold more frequently than controls or EM subjects, respectively. In conclusion, physical maltreatment was observed to interact with cerebellar morphology resulting in a strong association with alcohol and substance use. Lingula thickness may represent a novel, experientially sensitive, phenotypic risk factor for enhanced alcohol and drug use that perhaps modulates sensitivity to these agents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.