ArticleLipids2009
n-3 PUFA as regulators of cardiac gene transcription: a new link between PPAR activation and fatty acid composition.
Article in Lipids, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- BACE2 tunes lipid uptake through lipid transporters shedding supporting cancer cell proliferation.Journal of experimental & clinical cancer research : CR · 2026Article
- Docosahexaenoic Acid as Master Regulator of Cellular Antioxidant Defenses: A Systematic Review.Antioxidants (Basel, Switzerland) · 2023Review
- Effect of n-6/n-3 PUFA ratio on body fat deposition, tissues fatty acid composition and key genes expression of liver lipid metabolism in silver foxes (Frontiers in veterinary science · 2022Article
- Dietary α-Linolenic Acid Counters Cardioprotective Dysfunction in Diabetic Mice: Unconventional PUFA Protection.Nutrients · 2020Article
- Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction.Nutrition journal · 2019Observational
- High Fat Diet Dysregulates Hypothalamic-Pituitary Axis Gene Expression Levels which are Differentially Rescued by EPA and DHA Ethyl Esters.Molecular nutrition & food research · 2018Article
- Spaceflight Activates Lipotoxic Pathways in Mouse Liver.PloS one · 2016Article
- Dietary fatty acids alter left ventricular myocardial gene expression in Wistar rats.Nutrition research (New York, N.Y.) · 2014Article
- Coordination of gene expression of arachidonic and docosahexaenoic acid cascade enzymes during human brain development and aging.PloS one · 2014Article
- Fatty acid composition in fetal, neonatal, and cultured cardiomyocytes in rats.In vitro cellular & developmental biology. Animal · 2013Article
- Protective efficacy of orally administered, heat-killed Lactobacillus pentosus b240 against influenza A virus.Scientific reports · 2013Article
- Relationship between acute phase proteins and serum fatty acid composition in morbidly obese patients.Disease markers · 2013Article
- Obesity modifies the association between plasma phospholipid polyunsaturated fatty acids and markers of inflammation: the Multi-Ethnic Study of Atherosclerosis.International journal of obesity (2005) · 2012Article
- Article
- Omega 3 fatty acid inhibition of inflammatory cytokine-mediated Connexin43 regulation in the heart.Frontiers in physiology · 2012Article
- Fatty acid distribution of cord and maternal blood in human pregnancy: special focus on individual trans fatty acids and conjugated linoleic acids.Lipids in health and disease · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fatty acids regulate gene expression directly binding to nuclear receptors or affecting the protein content of transcription factors. In this work, supplementing primary cultures of neonatal rat cardiomyocytes with 60 microM EPA or DHA, we demonstrated by an ELISA assay an increased PPAR beta/delta binding to DNA. n-3 PUFA supplementation deeply changed the acyl composition of both cytosolic and nuclear fractions. The high content of total fatty acids, particularly EPA and DHA, and its increase following supplementation suggested a selective accumulation of n-3 PUFAs in the nucleus, supporting the direct interaction of n-3 PUFA with PPAR. The activity of acyl-CoA thioesterase (ACOT), catalyzing the reaction leading to NEFA from acyl-CoA, increased in n-3 PUFA supplemented cells. The NEFA/acyl-CoA ratio is an important regulator of the fatty acid transport to the nucleus and consequent modulation of gene transcription, and although ACOT activity is not the only parameter of this ratio, it is important for the control of the NEFA pool composition. Our data further clarify what happens in cardiomyocytes following n-3 PUFA supplementation, linking the modification of acyl composition to ACOT activity and PPAR activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.