ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2010
Atypical presentation of chronic granulomatous disease in an adolescent boy with frontal lobe located Aspergillus abscess mimicking intracranial tumor.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 32 citations in OpenAlex.
- Infectious Complications in Patients With Chronic Granulomatous Disease.Journal of the Pediatric Infectious Diseases Society · 2018Review
- Invasive Aspergillosis Mimicking Metastatic Lung Cancer.Frontiers in oncology · 2018Article
- Aspergillosis in Chronic Granulomatous Disease.Journal of fungi (Basel, Switzerland) · 2016Review
- Cranial metastatic alveolar rhabdomyosarcoma mimicking hematological malignancy in an adolescent boy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Neurological complication of non Hodgkin lymphoma in childhood: experience from a single center in Turkey.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Multiple fungal brain abscesses in a child with acute lymphoblastic leukemia.Mycopathologia · 2012Article
- Prostatic abscess in a pediatric patient with chronic granulomatous disease: report of a unique case and review of the literature.Journal of pediatric surgery · 2012Review
- Chronic granulomatous disease: a review of the infectious and inflammatory complications.Clinical and molecular allergy : CMA · 2011Article
- Fungal granuloma of the brain caused by Aspergillus in an adolescent boy with chronic granulomatous disease.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2010Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic granulomatous disease (CGD) is an uncommon congenital phagocyte disorder characterized by recurrent life-threatening infections. CGD generally present with recurrent suppurative infections, however, intracranial fungal abscess complicating CGD may cause a diagnostic problem to anyone unfamiliar with its clinical and radiological features. HISTORY: We report the case of a 16-year-old boy who was consulted with a differential diagnosis of an intracranial tumor. The clues of his medical history and physical examination made us consider the diagnosis of CGD. Cytometric dihydrorhodamine assay and genotyping confirmed an autosomal recessive CGD. He was successfully treated without any complication or sequel for 18 months follow-up period with surgery and interferon-gamma, in addition with, liposomal amphotericin B and voriconazole that were found to be sensitive to the Aspergillus fumigates, which had been grown from the culture of the abscess cavity. DISCUSSION: We discuss the pathogenesis, radiological techniques, and management of cerebral Aspergillus abscess in a patient with CGD.
conclusionPresentation of CGD with a cerebral Aspergillus abscess, mimicking a brain tumor is extremely rare in children; clinicians and neurosurgeons must be aware. The best management modality for cerebral Aspergillus abscess is to be vigilant about the disease, whereas adjuvant surgical and medical therapy with a close follow-up must be warranted for all cases.
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