ArticlePsychopharmacology2010
Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Genetic and epigenetic studies of opioid abuse disorder - the potential for future diagnostics.Expert review of molecular diagnostics · 2023Review
- Kappa Opioid Signaling at the Crossroads of Chronic Pain and Opioid Addiction.Handbook of experimental pharmacology · 2022Article
- Kappa opioid agonists reduce oxycodone self-administration in male rhesus monkeys.Psychopharmacology · 2020Article
- Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys by direct and indirect activation of 5-HT2C receptors.Psychopharmacology · 2015Article
- Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder.Pharmacological reviews · 2015Review
- Role of cues and contexts on drug-seeking behaviour.British journal of pharmacology · 2014Review
- Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models.British journal of pharmacology · 2014Review
- Drug withdrawal conceptualized as a stressor.Behavioural pharmacology · 2014Review
- Assessment of the kappa opioid agonist, salvinorin A, as a punisher of drug self-administration in monkeys.Psychopharmacology · 2014Article
- Efficacy of buspirone for attenuating cocaine and methamphetamine reinstatement in rats.Drug and alcohol dependence · 2013Article
- The macrocyclic peptide natural product CJ-15,208 is orally active and prevents reinstatement of extinguished cocaine-seeking behavior.Journal of natural products · 2013Article
- Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys.The Journal of pharmacology and experimental therapeutics · 2012Article
- The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.Cellular and molecular life sciences : CMLS · 2012Review
- Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Kappa Opioid Receptor-Mediated Disruption of Novel Object Recognition: Relevance for Psychostimulant Treatment.Journal of addiction research & therapy · 2011Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleKappa agonists can attenuate reinstatement of cocaine-seeking behavior induced by cocaine priming. The mechanisms underlying this effect have not been characterized fully but may have a serotonergic component as kappa agonists also increase the release of serotonin (5-hydroxytryptamine, 5-HT).
objectivesThis study investigated the role of kappa opioid receptor and 5-HT mechanisms in kappa agonist-induced attenuation of cocaine priming in monkeys.
methodsSquirrel monkeys were trained to self-administer cocaine (0.18-0.3 mg/kg/injection) under a second-order schedule in which drug seeking was maintained jointly by cocaine injections and a cocaine-paired visual stimulus. In extinction sessions, saline was substituted for cocaine, and the cocaine-paired stimulus was omitted. During test sessions, only saline was available for self-administration, and response-contingent presentations of the cocaine-paired stimulus were restored.
resultsPriming injections of cocaine (0.1-1.0 mg/kg) induced reinstatement of drug seeking. Maximal levels of responding were similar to those maintained by active cocaine self-administration. Pretreatment with the kappa agonists enadoline (0.01 mg/kg) and spiradoline (0.3 mg/kg) or the 5-HT transport inhibitors fluoxetine (5.6 mg/kg) and citalopram (10.0 mg/kg) attenuated the priming effects of cocaine, shifting the cocaine dose-response function rightward and downward. Inhibition of cocaine-induced reinstatement of drug seeking by spiradoline and fluoxetine was reversed by R(+)8-hydroxy-2-(di-n-propylamino)tetralin (0.03 mg/kg), a 5HT(1A) agonist that inhibits 5-HT release. The effects of spiradoline also were reversed by the kappa antagonist nor-binaltorphimine (10.0 mg/kg).
conclusionsResults suggest that the capacity of kappa opioid agonists to increase extracellular 5-HT levels may at least partially underlie kappa agonist-induced modulation of cocaine seeking.
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