ArticleGenetics2010
Defining and mapping mammalian coat pattern genes: multiple genomic regions implicated in domestic cat stripes and spots.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- Review
- A Genomic Exploration of the Possible De-Extirpation of the Zanzibar Leopard.Molecular ecology · 2025Article
- Camouflage or Coincidence? Investigating the Effects of Spatial and Temporal Environmental Features on Feral Cat Morphology in Tasmania.Ecology and evolution · 2024Article
- Color polymorphic carnivores have faster speciation rates.Scientific reports · 2024Article
- Toward telomere-to-telomere cat genomes for precision medicine and conservation biology.Genome research · 2024Review
- Heterozygosity is low where rare color variants in wild carnivores prevail.Ecology and evolution · 2024Article
- Molecular tracking and prevalence of the red colour morph restricted to a harvested leopard population in South Africa.Evolutionary applications · 2022Article
- Developmental genetics of color pattern establishment in cats.Nature communications · 2021Article
- Mining the 99 Lives Cat Genome Sequencing Consortium database implicates genes and variants for the Ticked locus in domestic cats (Felis catus).Animal genetics · 2021Article
- Mapping the genetic basis of diabetes mellitus in the Australian Burmese cat (Felis catus).Scientific reports · 2020Article
- Periodic patterns in Rodentia: Development and evolution.Experimental dermatology · 2019Article
- Distinguishing the victim from the threat: SNP-based methods reveal the extent of introgressive hybridization between wildcats and domestic cats in Scotland and inform future in situ and ex situ management options for species restoration.Evolutionary applications · 2019Article
- Article
- Beauty ranking of mammalian species kept in the Prague Zoo: does beauty of animals increase the respondents' willingness to protect them?Die Naturwissenschaften · 2018Article
- Article
- Characterization of an Early-Onset, Autosomal Recessive, Progressive Retinal Degeneration in Bengal Cats.Investigative ophthalmology & visual science · 2015Article
- Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats.G3 (Bethesda, Md.) · 2014Article
- Article
- Genetic architecture of skewed X inactivation in the laboratory mouse.PLoS genetics · 2013Article
- Genetic testing in domestic cats.Molecular and cellular probes · 2012Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Mammalian coat patterns (e.g., spots, stripes) are hypothesized to play important roles in camouflage and other relevant processes, yet the genetic and developmental bases for these phenotypes are completely unknown. The domestic cat, with its diversity of coat patterns, is an excellent model organism to investigate these phenomena. We have established three independent pedigrees to map the four recognized pattern variants classically considered to be specified by a single locus, Tabby; in order of dominance, these are the unpatterned agouti form called "Abyssinian" or "ticked" (T(a)), followed by Spotted (T(s)), Mackerel (T(M)), and Blotched (t(b)). We demonstrate that at least three different loci control the coat markings of the domestic cat. One locus, responsible for the Abyssinian form (herein termed the Ticked locus), maps to an approximately 3.8-Mb region on cat chromosome B1. A second locus controls the Tabby alleles T(M) and t(b), and maps to an approximately 5-Mb genomic region on cat chromosome A1. One or more additional loci act as modifiers and create a spotted coat by altering mackerel stripes. On the basis of our results and associated observations, we hypothesize that mammalian patterned coats are formed by two distinct processes: a spatially oriented developmental mechanism that lays down a species-specific pattern of skin cell differentiation and a pigmentation-oriented mechanism that uses information from the preestablished pattern to regulate the synthesis of melanin profiles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.