Evidence map›Paper›PMID 19858250›Full record

ArticleAntimicrobial agents and chemotherapy2010

Pharmacokinetic properties of azithromycin in pregnancy.

Sam Salman, Stephen J Rogerson, Kay Kose, Susan Griffin, Servina Gomorai, Francesca Baiwog, Josephine Winmai, Josin Kandai, Harin A Karunajeewa, Sean J O'Halloran and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sam SalmanSchool of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
Stephen J Rogerson
Kay Kose
Susan Griffin
Servina Gomorai
Francesca Baiwog
Josephine Winmai
Josin Kandai
Harin A Karunajeewa
Sean J O'Halloran
Peter Siba
Kenneth F Ilett
Ivo Mueller
Timothy M E Davis

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Azithromycin (AZI) is an azalide antibiotic with antimalarial activity that is considered safe in pregnancy. To assess its pharmacokinetic properties when administered as intermittent preventive treatment in pregnancy (IPTp), two 2-g doses were given 24 h apart to 31 pregnant and 29 age-matched nonpregnant Papua New Guinean women. All subjects also received single-dose sulfadoxine-pyrimethamine (SP) (1,500 mg or 75 mg) or chloroquine (450-mg base daily for 3 days). Blood samples were taken at 0, 1, 2, 3, 6, 12, 24, 32, 40, 48, and 72 h and on days 4, 5, 7, 10, and 14 for AZI assay by ultra-high-performance liquid chromatography-tandem mass spectrometry. The treatments were well tolerated. Using population pharmacokinetic modeling, a three-compartment model with zero-order followed by first-order absorption and no lag time provided the best fit. The areas under the plasma concentration-time curve (AUC(0-infinity)) (28.7 and 31.8 mg.h liter(-1) for pregnant and nonpregnant subjects, respectively) were consistent with the results of previous studies, but the estimated terminal elimination half-lives (78 and 77 h, respectively) were generally longer. The only significant relationship for a range of potential covariates, including malarial parasitemia, was with pregnancy, which accounted for an 86% increase in the volume of distribution of the central compartment relative to bioavailability without a significant change in the AUC(0-infinity). These data suggest that AZI can be combined with compounds with longer half-lives, such as SP, in combination IPTp without the need for dose adjustment.

Indexed as

AdultAntimalarialsArea Under CurveAzithromycinChloroquineChromatography, High Pressure LiquidDrug CombinationsFemaleHalf-LifeHumansIntestinal AbsorptionModels, StatisticalPapua New GuineaPregnancyPyrimethamineSulfadoxineAntimalarialsAzithromycinChloroquineDrug CombinationsPyrimethamineSulfadoxine

Identifiers

PMID19858250
PMCPMC2798488

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.