Trial reportChest2010
Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury.
Trial report in Chest, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02625064 (Discovery of New Early Detection Biomarkers of Acute Respiratory Distress Syndrome), which is not on this map. Cited by 151 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Discovery of New Early Detection Biomarkers of Acute Respiratory Distress Syndrome
Who cites it
151 citing papers in PubMed, 2 syntheses or guidelines pooled it, 284 citations in OpenAlex.
- A systematic review of biomarkers multivariately associated with acute respiratory distress syndrome development and mortality.Critical care (London, England) · 2020Pooled it
- Is omega-3 fatty acids enriched nutrition support safe for critical ill patients? A systematic review and meta-analysis.Nutrients · 2014Pooled it
- Development and validation of a clinical risk model to predict the hospital mortality in ventilated patients with acute respiratory distress syndrome: a population-based study.BMC pulmonary medicine · 2022Trial
- Effect of Oral Glucose Water Administration 1 Hour Preoperatively in Children with Cyanotic Congenital Heart Disease: A Randomized Controlled Trial.Medical science monitor : international medical journal of experimental and clinical research · 2020Trial
- Trial
- Trial
- Effects of a recruitment maneuver on plasma levels of soluble RAGE in patients with diffuse acute respiratory distress syndrome: a prospective randomized crossover study.Intensive care medicine · 2015Trial
- Trial
- Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs.Anesthesiology · 2014Trial
- Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.The Lancet. Respiratory medicine · 2014Trial
- Immunophenotyping and protein profiling of Fontan-associated plastic bronchitis airway casts.Annals of the American Thoracic Society · 2013Trial
- Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials.American journal of physiology. Lung cellular and molecular physiology · 2012Trial
- Interleukin-6 is a mediator of therapeutic efficacy in acute lung injury.American journal of respiratory and critical care medicine · 2026Article
- Neutrophil-macrophage crosstalk network in acute lung injury: feedback circuits linking cytokine storm and cell death.Frontiers in cellular and infection microbiology · 2026Review
- Enhanced application potential of alveolar organoids through epithelial and niche cell interactions.Scientific reports · 2025Article
- Association of Albumin-Bilirubin (ALBI) Grade With 28-Day All-Cause Mortality in Patients With Acute Respiratory Distress Syndrome: A Retrospective Analysis of the MIMIC-IV Database.Mediators of inflammation · 2025Article
- Early predictive values of clinical assessments for ARDS mortality: a machine-learning approach.Scientific reports · 2024Observational
- 21st century critical care medicine: An overview.World journal of critical care medicine · 2024Review
- Prone Positioning and Molecular Biomarkers in COVID and Non-COVID ARDS: A Narrative Review.Journal of clinical medicine · 2024Review
- Alveolar-arterial oxygen gradient nonlinearly impacts the 28-day mortality of patients with sepsis: Secondary data mining based on the MIMIC-IV database.The clinical respiratory journal · 2023Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundNo single clinical or biologic marker reliably predicts clinical outcomes in acute lung injury (ALI)/ARDS. We hypothesized that a combination of biologic and clinical markers would be superior to either biomarkers or clinical factors alone in predicting ALI/ARDS mortality and would provide insight into the pathogenesis of clinical ALI/ARDS.
methodsEight biologic markers that reflect endothelial and epithelial injury, inflammation, and coagulation (von Willebrand factor antigen, surfactant protein D [SP-D]), tumor necrosis factor receptor-1, interleukin [IL]-6, IL-8, intercellular adhesion molecule-1, protein C, plasminogen activator inhibitor-1) were measured in baseline plasma from 549 patients in the ARDSNet trial of low vs high positive end-expiratory pressure. Mortality was modeled with multivariable logistic regression. Predictors were selected using backward elimination. Comparisons between candidate models were based on the receiver operating characteristics (ROC) and tests of integrated discrimination improvement.
resultsClinical predictors (Acute Physiology And Chronic Health Evaluation III [APACHE III], organ failures, age, underlying cause, alveolar-arterial oxygen gradient, plateau pressure) predicted mortality with an area under the ROC curve (AUC) of 0.82; a combination of eight biomarkers and the clinical predictors had an AUC of 0.85. The best performing biomarkers were the neutrophil chemotactic factor, IL-8, and SP-D, a product of alveolar type 2 cells, supporting the concept that acute inflammation and alveolar epithelial injury are important pathogenetic pathways in human ALI/ARDS.
conclusionsA combination of biomarkers and clinical predictors is superior to clinical predictors or biomarkers alone for predicting mortality in ALI/ARDS and may be useful for stratifying patients in clinical trials. From a pathogenesis perspective, the degree of acute inflammation and alveolar epithelial injury are highly associated with the outcome of human ALI/ARDS.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.