Evidence map›Paper›PMID 19858174›Full record

Trial reportBMJ (Clinical research ed.)2009

Food incentives to improve completion of tuberculosis treatment: randomised controlled trial in Dili, Timor-Leste.

Nelson Martins, Peter Morris, Paul M Kelly

Erratum issued 2 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 49 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00192556 nacompletednot on this map

Food Incentives for TB Treatment Compliance in East Timor

TypeinterventionalSponsorMenzies School of Health ResearchRan2005 to 2006Enrolled270ConditionsTuberculosisArmsfood
NCT02554318 nacompletednot on this mapstarted 2013, after this paper: background citation

The Effect of Fermented Soybean Supplementation on the Body Weight and Physical Function of Tuberculosis Patients With Standard Therapy in Indonesia

TypeinterventionalSponsorUniversity of GiessenRan2013 to 2015Enrolled147ConditionsPulmonary Tuberculosis, Body Weight Changes, Motor ActivityArmsRifampicin, Isoniazid, Pyrazinamide, Ethambutol, Fermented soybean
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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  7. Guideline
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  9. Nutritional supplements for people being treated for active tuberculosis.The Cochrane database of systematic reviews · 2016
    Pooled it
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  11. Incentives and enablers to improve adherence in tuberculosis.The Cochrane database of systematic reviews · 2015
    Pooled it
  12. Interventions for enhancing medication adherence.The Cochrane database of systematic reviews · 2014
    Pooled it
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  15. Tuberculosis (HIV-negative people).BMJ clinical evidence · 2011
    Pooled it
  16. Patient-Centered Outcomes of Medication Adherence Interventions: Systematic Review and Meta-Analysis.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
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  17. Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Nelson MartinsMenzies School of Health Research, Darwin, NT, Australia.
Peter Morris
Paul M Kelly

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the effectiveness of the provision of whole food to enhance completion of treatment for tuberculosis.

designParallel group randomised controlled trial.

settingThree primary care clinics in Dili, Timor-Leste.

participants270 adults aged >or=18 with previously untreated newly diagnosed pulmonary tuberculosis.

main outcome measuresCompletion of treatment (including cure). Secondary outcomes included adherence to treatment, weight gain, and clearance of sputum smears. Outcomes were assessed remotely, blinded to allocation status. Interventions Participants started standard tuberculosis treatment and were randomly assigned to intervention (nutritious, culturally appropriate daily meal (weeks 1-8) and food package (weeks 9-32) (n=137) or control (nutritional advice, n=133) groups. Randomisation sequence was computer generated with allocation concealment by sequentially numbered, opaque, sealed envelopes.

resultsMost patients with tuberculosis were poor, malnourished men living close to the clinics; 265/270 (98%) contributed to the analysis. The intervention had no significant beneficial or harmful impact on the outcome of treatment (76% v 78% completion, P=0.7) or adherence (93% for both groups, P=0.7) but did lead to improved weight gain at the end of treatment (10.1% v 7.5% improvement, P=0.04). Itch was more common in the intervention group (21% v 9%, P<0.01). In a subgroup analysis of patients with positive results on sputum smears, there were clinically important improvements in one month sputum clearance (85% v 67%, P=0.13) and completion of treatment (78% v 68%, P=0.3).

conclusionProvision of food did not improve outcomes with tuberculosis treatment in these patients in Timor-Leste. Further studies in different settings and measuring different outcomes are required.

trial registrationClinical Trials NCT00192556.

Indexed as

FoodMedication AdherenceMotivationAdultAgedAntitubercular AgentsFemaleHumansMaleMiddle AgedSputumTreatment OutcomeTuberculosis, Multidrug-ResistantTuberculosis, PulmonaryWeight GainYoung AdultAntitubercular Agents

Identifiers

PMID19858174
PMCPMC2767482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.