ReviewProgress in neurobiology2010
The TIP39-PTH2 receptor system: unique peptidergic cell groups in the brainstem and their interactions with central regulatory mechanisms.
Review in Progress in neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between hypoparathyroidism and cognitive impairment: a systematic review.Journal of endocrinological investigation · 2021Pooled it
- Neuropsychiatric manifestations of primary hyperparathyroidism.Wiener klinische Wochenschrift · 2026Review
- Article
- Parathyroid Hormone as a Modulator of Skeletal Muscle: Insights into Bone-Muscle and Nerve-Muscle Interactions.International journal of molecular sciences · 2025Review
- Review
- Neuropeptide TIP39 as a pluripotent brain molecule and its potential functions in postpartum depression.Frontiers in endocrinology · 2025Review
- Review
- Performance in Behavioral Testing in an Animal Model of Post-Surgical Hypoparathyroidism.Journal of personalized medicine · 2024Article
- Synaptoporin and parathyroid hormone 2 as markers of multimodal inputs to the auditory brainstem.Journal of chemical neuroanatomy · 2023Article
- Parathyroid Hormone (PTH)-Related Peptides Family: An Intriguing Role in the Central Nervous System.Journal of personalized medicine · 2023Review
- Cognitive deficits in primary hyperparathyroidism - what we know and what we do not know: A narrative review.Reviews in endocrine & metabolic disorders · 2022Review
- Behavioural actions of tuberoinfundibular peptide 39 (parathyroid hormone 2).Journal of neuroendocrinology · 2022Review
- Connections of the mouse subfornical region of the lateral hypothalamus (LHsf).Brain structure & function · 2021Article
- Secretion and Function of Pituitary Prolactin in Evolutionary Perspective.Frontiers in neuroscience · 2020Review
- Thalamic integration of social stimuli regulating parental behavior and the oxytocin system.Frontiers in neuroendocrinology · 2018Review
- A Novel Perspective Linkage Between Kidney Function and Alzheimer's Disease.Frontiers in cellular neuroscience · 2018Article
- Anatomical Evidence for a Direct Projection from Purkinje Cells in the Mouse Cerebellar Vermis to Medial Parabrachial Nucleus.Frontiers in neural circuits · 2018Article
- Maternally involved galanin neurons in the preoptic area of the rat.Brain structure & function · 2017Article
- A Thalamo-Hypothalamic Pathway That Activates Oxytocin Neurons in Social Contexts in Female Rats.Endocrinology · 2017Article
- Bovine parathyroid hormone enhances osteoclast bone resorption by modulating V-ATPase through PTH1R.International journal of molecular medicine · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Tuberoinfundibular peptide of 39 residues (TIP39) is the recently purified endogenous ligand of the previously orphan G-protein coupled parathyroid hormone 2 receptor (PTH2R). The TIP39-PTH2R system is a unique neuropeptide-receptor system whose localization and functions in the central nervous system are different from any other neuropeptides. TIP39 is expressed in two brain regions, the subparafascicular area in the posterior thalamus, and the medial paralemniscal nucleus in the lateral pons. Subparafascicular TIP39 neurons seem to divide into a medial and a lateral cell population in the periventricular gray of the thalamus, and in the posterior intralaminar complex of the thalamus, respectively. Periventricular thalamic TIP39 neurons project mostly to limbic brain regions, the posterior intralaminar thalamic TIP39 neurons to neuroendocrine brain areas, and the medial paralemniscal TIP39 neurons to auditory and other brainstem regions, and the spinal cord. The widely distributed axon terminals of TIP39 neurons have a similar distribution as the PTH2R-containing neurons, and their fibers, providing the anatomical basis of a neuromodulatory action of TIP39. Initial functional studies implicated the TIP39-PTH2R system in nociceptive information processing in the spinal cord, in the regulation of different hypophysiotropic neurons in the hypothalamus, and in the modulation of affective behaviors. Recently developed novel experimental tools including mice with targeted mutations of the TIP39-PTH2R system and specific antagonists of the PTH2R will further facilitate the identification of the specific roles of TIP39 and the PTH2R.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.