ArticleNutrition journal2009
Influence of the calcium concentration in the presence of organic phosphorus on the physicochemical compatibility and stability of all-in-one admixtures for neonatal use.
Article in Nutrition journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Trial
- Changes in Biochemical Parameters of the Calcium-Phosphorus Homeostasis in Relation to Nutritional Intake in Very-Low-Birth-Weight Infants.Nutrients · 2016Trial
- Comprehensive assessment and prediction of calcium-phosphorus precipitation in parenteral nutrition using advanced monitoring and data mining techniques.Frontiers in nutrition · 2026Article
- Optical Microscopy as a Tool for Assessing Parenteral Nutrition Solution Stability: A Proof of Concept.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Electron Microscopy for the Stability Assessment of Parenteral Nutrition Admixtures: Focus on Precipitation.Nutrients · 2024Article
- Physicochemical Stability of Hospital Parenteral Nutrition Solutions: Effect of Changes in Composition and Storage Protocol.Pharmaceutics · 2024Article
- Evaluation of the Stability of Newborn Hospital Parenteral Nutrition Solutions.Pharmaceutics · 2024Article
- Compatibility of Maximum Inorganic and Organic Calcium and Phosphate Content in Neonatal Parenteral Solutions.Scientific reports · 2019Article
- Pharmaceutical point of view on parenteral nutrition.TheScientificWorldJournal · 2013Review
- Evaluation of parenteral nutritional support in the surgical and medical wards of a referral teaching hospital.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2012Article
- Influence of the relative composition of trace elements and vitamins in physicochemical stability of total parenteral nutrition formulations for neonatal use.Nutrition journal · 2012Article
- Chemical stability study of vitamins thiamine, riboflavin, pyridoxine and ascorbic acid in parenteral nutrition for neonatal use.Nutrition journal · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreterm infants need high amounts of calcium and phosphorus for bone mineralization, which is difficult to obtain with parenteral feeding due to the low solubility of these salts. The objective of this study was to evaluate the physicochemical compatibility of high concentrations of calcium associated with organic phosphate and its influence on the stability of AIO admixtures for neonatal use.
methodsThree TPN admixture formulas were prepared in multilayered bags. The calcium content of the admixtures was adjusted to 0, 46.5 or 93 mg/100 ml in the presence of a fixed organic phosphate concentration as well as lipids, amino acids, inorganic salts, glucose, vitamins and oligoelements at pH 5.5. Each admixture was stored at 4 degrees C, 25 degrees C or 37 degrees C and evaluated over a period of 7 days. The physicochemical stability parameters evaluated were visual aspect, pH, sterility, osmolality, peroxide formation, precipitation, and the size of lipid globules.
resultsColor alterations occurred from the first day on, and reversible lipid film formation from the third day of study for the admixtures stored at 25 degrees C and 37 degrees C. According to the parameters evaluated, the admixtures were stable at 4 degrees C; and none of them presented precipitated particles due to calcium/phosphate incompatibility or lipid globules larger than 5 mum, which is the main parameter currently used to evaluate lipid emulsion stability. The admixtures maintained low peroxide levels and osmolarity was appropriate for parenteral administration.
conclusionThe total calcium and calcium/phosphorus ratios studied appeared not to influence the physicochemical compatibility and stability of AIO admixtures.
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