ArticleChembiochem : a European journal of chemical biology2009
Synthesis, conjugation, and immunological evaluation of the serogroup 6 pneumococcal oligosaccharides.
Article in Chembiochem : a European journal of chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Chemical Synthesis of Truncated Capsular Oligosaccharide of Serotypes 6C and 6D ofACS infectious diseases · 2024Article
- Synthesis and Preliminary Immunological Evaluation of a Pseudotetrasaccharide Related to a Repeating Unit of theFrontiers in molecular biosciences · 2021Article
- Synthetic Analogs ofRussian journal of bioorganic chemistry · 2021Article
- Synthetic avenues towards a tetrasaccharide related toBeilstein journal of organic chemistry · 2018Article
- Conjugate Vaccines from Bacterial Antigens by Squaric Acid Chemistry: A Closer Look.Chembiochem : a European journal of chemical biology · 2017Article
- Glycosyl Thioimidates as Versatile Building Blocks for Organic Synthesis.Chemistry of heterocyclic compounds · 2012Article
- Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for 2009-2010.Mass spectrometry reviewsReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The first synthesis of the newly discovered oligosaccharide of pneumococcal serotype 6C and its spacer-containing analogue is reported. Conjugation of the spacer-containing oligosaccharides of pneumococcal saccharides 6A, 6B, 6C and derivatives thereof with bovine serum albumin (BSA) protein carrier was carried out by using squaric-acid approach to obtain the oligosaccharide-protein conjugates in excellent yields. The conjugates have been tested with a rabbit antiserum pool (Pool B) used for pneumococcal serotyping. The results showed that synthetic carbohydrate conjugates express epitopes found in native capsular polysaccharides of serotypes 6A, 6B, and 6C.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.