ArticleEndocrine2009
Autonomic activity and glycemic homeostasis are maintained by precocious and low intensity training exercises in MSG-programmed obese mice.
Article in Endocrine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- The Duodenum-Centered Neurohormonal Hypothesis of Type 2 Diabetes: A Mechanistic Review and Therapeutic Perspective.Current issues in molecular biology · 2025Review
- Vagal Splenic-Dependent Effects Influence Glucose Homeostasis, Insulin Secretion, and Histopathology of the Endocrine Pancreas in Hypothalamic Obese Male Rats: Vagus Nerve and Spleen Interactions Affect the Endocrine Pancreas.TheScientificWorldJournal · 2025Article
- Lean in one way, in obesity another: effects of moderate exercise in brown adipose tissue of early overfed male Wistar rats.International journal of obesity (2005) · 2022Article
- DUODENAL-JEJUNAL BYPASS REDUCES LIPID ACCUMULATION IN THE BROWN ADIPOSE TISSUE OF HYPOTHALAMIC OBESE RATS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2020Article
- Maternal low intensity physical exercise prevents obesity in offspring rats exposed to early overnutrition.Scientific reports · 2017Article
- Glibenclamide treatment blocks metabolic dysfunctions and improves vagal activity in monosodium glutamate-obese male rats.Endocrine · 2017Article
- Vagotomy diminishes obesity in cafeteria rats by decreasing cholinergic potentiation of insulin release.Journal of physiology and biochemistry · 2016Article
- Short-term moderate exercise provides long-lasting protective effects against metabolic dysfunction in rats fed a high-fat diet.European journal of nutrition · 2015Article
- Early redox imbalance is associated with liver dysfunction at weaning in overfed rats.The Journal of physiology · 2015Article
- Vagotomy ameliorates islet morphofunction and body metabolic homeostasis in MSG-obese rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- Duodenal-jejunal bypass restores insulin action and βeta-cell function in hypothalamic-obese rats.Obesity surgery · 2015Article
- Low-intensity and moderate exercise training improves autonomic nervous system activity imbalanced by postnatal early overfeeding in rats.Journal of the International Society of Sports Nutrition · 2014Article
- Impaired muscarinic type 3 (M3) receptor/PKC and PKA pathways in islets from MSG-obese rats.Molecular biology reports · 2013Article
- Swim training of monosodium L-glutamate-obese mice improves the impaired insulin receptor tyrosine phosphorylation in pancreatic islets.Endocrine · 2013Article
- Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life.Nutrition & metabolism · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current research employed electrical records from superior vagus and sympathetic nerve branch that supply fat retroperitoneal tissue (RS nerve) to investigate whether very moderate swim training in obese-programmed mice would change sympathetic and parasympathetic autonomic nervous system activities. Neonatal mice were treated with monosodium L: -glutamate (MSG), during their first 5 days of life, to induce obesity. Mice started training on weaning, comprising free swimming 3 days/week, 15 min/day for 10 weeks. After 12 h fasting, the nerve electrical signals of the 90-day-old mice were processed to obtain firing rates. Blood samples were collected to measure glucose and insulin levels. Adrenal catecholamine content was measured. MSG treatment caused obesity. Hyperglycemia and hyperinsulinemia in MSG-obese mice, without any change in food intake, were obtained. Vagus firing rates were higher in obese mice than those in lean ones. A decrease in RS nerve activity and lower adrenal catecholamine stores have been observed. Swimming normalized blood glucose and insulin levels and MSG-obesity onset was attenuated by exercise. Vagus activity from obese mice decreased, whereas RS nerve activity and adrenal catecholamine levels increased in trained ones. Results suggest that autonomic activity imbalance and metabolic dysfunctions observed in MSG-obese mice were inhibited by precocious and moderate exercise training.
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