ArticleNeurochemical research2010
Nucleoside map of the human central nervous system.
Article in Neurochemical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Putative Role of Adenosine A1 Receptors in Exogenous Ketone Supplements-Evoked Anti-Epileptic Effect.International journal of molecular sciences · 2024Review
- Article
- Purine-related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology.Brain pathology (Zurich, Switzerland) · 2018Article
- Signaling pathways underlying the antidepressant-like effect of inosine in mice.Purinergic signalling · 2017Article
- Fast-scan Cyclic Voltammetry for the Characterization of Rapid Adenosine Release.Computational and structural biotechnology journal · 2015Review
- Characterization of spontaneous, transient adenosine release in the caudate-putamen and prefrontal cortex.PloS one · 2014Article
- The antidepressant-like effect of inosine in the FST is associated with both adenosine A1 and A 2A receptors.Purinergic signalling · 2013Article
- The mechanism of electrically stimulated adenosine release varies by brain region.Purinergic signalling · 2013Article
- Identification of a lacosamide binding protein using an affinity bait and chemical reporter strategy: 14-3-3 ζ.Journal of the American Chemical Society · 2011Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleosides are neuromodulators that have a wide range of biological roles in the brain. In order to better understand the function of nucleosides in the human central nervous system (CNS), we constructed a nucleoside map showing the concentration of various nucleosides and their metabolites using post mortem samples from 61 human brain areas and 4 spinal cord areas. We evaluated in vivo tissue levels of four nucleosides (uridine, inosine, guanosine, and adenosine) and three of their metabolites (uracil, hypoxanthine, and xanthine). The concentrations of nucleosides were unevenly distributed across different brain regions, where the highest levels were found in the cerebral cortex and basal ganglia, whereas the lowest concentrations were located in the locus coeruleus, the zona incerta, the substantia nigra, and the inferior colliculus. The regional differences in nucleoside levels in the CNS may reflect the distinct physiological functions adopted by these compounds in different brain areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.