ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2010
Beyond epithelial to mesenchymal transition: a novel role for the transcription factor Snail in inflammation and wound healing.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Conserved stromal EMT program controls regenerative capacity of mesenchymal stromal cells across multiple tissues.Science advances · 2026Article
- A unique cell population expressing the Epithelial-Mesenchymal Transition-transcription factor Snail moderates microglial and astrocyte injury responses.PNAS nexus · 2023Article
- Analyzing the role of cancer-associated fibroblast activation on macrophage polarization.Molecular oncology · 2023Article
- Dynamic polarization of tumor-associated macrophages and their interaction with intratumoral T cells in an inflamed tumor microenvironment: from mechanistic insights to therapeutic opportunities.Frontiers in immunology · 2023Review
- Slug and Snail have differential effects in directing colonic epithelial wound healing and partially mediate the restitutive effects of butyrate.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Review
- The role of the epithelial-to-mesenchymal transition (EMT) in diseases of the salivary glands.Histochemistry and cell biology · 2018Review
- SNAIL1 action in tumor cells influences macrophage polarization and metastasis in breast cancer through altered GM-CSF secretion.Oncogenesis · 2018Article
- Shift of EMT gradient in 3D spheroid MSCs for activation of mesenchymal niche function.Scientific reports · 2017Article
- TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype.Oncotarget · 2016Article
- The network of epithelial-mesenchymal transition: potential new targets for tumor resistance.Journal of cancer research and clinical oncology · 2015Review
- Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis.Mucosal immunology · 2015Article
- Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.Science (New York, N.Y.) · 2014Article
- The importance of the retinoid X receptor alpha in modulating inflammatory signaling in acute murine colitis.Digestive diseases and sciences · 2014Article
- Is RXRα crucially involved in intestinal inflammation?Digestive diseases and sciences · 2014Article
- Vitamin D receptor and retinoid X receptor α status and vitamin D insufficiency in models of murine colitis.Cancer prevention research (Philadelphia, Pa.) · 2013Article
- Similar cellular migration patterns from niches in intervertebral disc and in knee-joint regions detected by in situ labeling: an experimental study in the New Zealand white rabbit.Stem cell research & therapy · 2013Article
- Tubular cell dedifferentiation and peritubular inflammation are coupled by the transcription regulator Id1 in renal fibrogenesis.Kidney international · 2012Article
- Role of tumor-associated macrophages in the progression of hepatocellular carcinoma.Surgery today · 2012Review
- Snail: More than EMT.Cell adhesion & migrationReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSnail, a transcription factor linked to epithelial to mesenchymal transition (EMT) during embryonic development and tumor progression, is associated with migration of cells. During inflammation and tissue injury, cell movement is also observed to provide the first line of defense against bacteria and to promote wound healing. Therefore, we studied the function of Snail in activated macrophages in a variety of inflammatory processes. MATERIALS AND
methodsIn this study, we examined the expression and localization of Snail during inflammation and tissue injury in rats and human tissue specimens, by immunohistochemistry, Western blot, and real-time PCR. We investigated Snail expression after stimulation of macrophages with TGF-beta1, LPS, Interleukin-8, and MMP-3 in vitro. To further understand the role of Snail in activated macrophages, we used Stealth siRNA against Snail, transfected the human macrophage cell line THP-1, and measured migration of cells in an in vitro invasion assay. RESULTS AND DISCUSSION: We found a strong, transient, and time-dependent activation of Snail in migrating macrophages at the sites of injury in vivo and in vitro, as well as in patients with inflammatory bowel disease. Furthermore, we showed that induction of Snail in macrophages is dependent on TGF-beta1 signaling pathway. Downregulation of Snail by Stealth siRNA led to impaired migration of THP-1 cells in an invasion assay after stimulation with TGF-beta1.
conclusionWe conclude that TGF-beta1 induced migration of activated macrophages during inflammation and wound healing is mediated by snail. These results give insights in a novel EMT-like mechanism present in immune cell movement during tissue injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.