ReviewDer Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft2009
[Meibomian glands. Part II: physiology, characteristics, distribution and function of meibomian oil].
Review in Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- A spectroscopic approach to measuring meibum lipid composition and conformation in donors with Sjӧgren's syndrome.Experimental eye research · 2021Article
- Deficiency in Acyl-CoA:Wax Alcohol Acyltransferase 2 causes evaporative dry eye disease by abolishing biosynthesis of wax esters.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Dry Eye Disease: A Review of Epidemiology in Taiwan, and its Clinical Treatment and Merits.Journal of clinical medicine · 2019Review
- Lipid Saturation and the Rheology of Human Tear Lipids.International journal of molecular sciences · 2019Article
- Influence of glaucoma surgery on the ocular surface using oculus keratograph.International ophthalmology · 2019Article
- TearCareClinical ophthalmology (Auckland, N.Z.) · 2019Article
- The prevalence of meibomian gland dysfunction, tear film and ocular surface parameters in an Austrian dry eye clinic population.Acta ophthalmologica · 2018Article
- A novel system, TearCareClinical ophthalmology (Auckland, N.Z.) · 2018Article
- Eyelid cleansing with ointment for obstructive meibomian gland dysfunction.Japanese journal of ophthalmology · 2017Article
- Dissecting lipid metabolism in meibomian glands of humans and mice: An integrative study reveals a network of metabolic reactions not duplicated in other tissues.Biochimica et biophysica acta · 2016Article
- Sebum/Meibum Surface Film Interactions and Phase Transitional Differences.Investigative ophthalmology & visual science · 2016Article
- A unique lineage gives rise to the meibomian gland.Molecular vision · 2016Article
- Surface Properties of Squalene/Meibum Films and NMR Confirmation of Squalene in Tears.International journal of molecular sciences · 2015Article
- [Testosterone reduces the expression of keratinization-promoting genes in murine Meibomian glands].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2013Article
- Activities of autonomic neurotransmitters in Meibomian gland tissues are associated with menopausal dry eye.Neural regeneration research · 2012Article
- Evaluation and quantitation of intact wax esters of human meibum by gas-liquid chromatography-ion trap mass spectrometry.Investigative ophthalmology & visual science · 2012Article
- High resolution microscopy of the lipid layer of the tear film.The ocular surface · 2011Article
- Lipidomics of human Meibomian gland secretions: Chemistry, biophysics, and physiological role of Meibomian lipids.Progress in lipid research · 2011Review
- Changes in gene expression in human meibomian gland dysfunction.Investigative ophthalmology & visual science · 2011Article
- The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland.Investigative ophthalmology & visual science · 2011Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oily secretion (meibum) of the Meibomian glands forms the superficial layer of the pre-ocular tear film and reduces evaporation of the aqueous phase. Meibum is a complex mixture of various lipids and minor protein components as well as other components of the secretory meibocytes, which form a clear liquid at body temperature. The exact composition and functions of meibum are still partly unknown, in particular the interaction of the water insoluble non-polar lipids with the polar, partly water soluble, lipids and potentially with proteins, which altogether interact to maintain the connection with the underlying aqueous tear phase. Meibum is transported within the gland by the force of secretory pressure from continuous secretion and by muscular action of the orbicularis muscle and Riolans muscles during blinking. After delivery of meibum onto the posterior lid margin the oil moves from the posterior lid margin reservoir onto the tear meniscus and is pulled as a thin layer onto the pre-ocular tear film every time the lid opens. During lid closure it is compressed and a small part is continuously renewed. Meibum also has a barrier function against the spillage of tears over the inner border of the lid and against the entry of skin lipids (sebum) from the free lid margin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.