ReviewDer Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft2009
[Meibomian glands. Part I: anatomy, embryology and histology of the Meibomian glands].
Review in Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 78 citations in OpenAlex.
- Intracrine androgen metabolism in the meibomian gland: regulation, circadian control, and implications in dry eye disease.Endocrine journal · 2026Review
- Review
- A Comprehensive Analysis of Meibomian Gland Function, Corneal Sensitivity, and Tear Parameters in Early-Stage Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Applied anatomy and morphology of Meibomian glands in the non-human primate.Scientific reports · 2025Article
- Comparative Analysis of Age-Associated Changes in Meibum Composition, Distribution, and Function in Mice With Altered Hyaluronan Expression.Investigative ophthalmology & visual science · 2025Article
- Performance of a novel multimodal large language model in ınterpreting meibomian glands quantitatively and qualitatively.International ophthalmology · 2025Article
- Instability of tear film and loss of meibomian glands in patients with acne vulgaris.Arquivos brasileiros de oftalmologia · 2022Article
- Review
- Differential effects of dietary cholesterol and triglycerides on the lipid homeostasis in Meibomian glands.The Journal of steroid biochemistry and molecular biology · 2021Article
- Depletion of Cholesteryl Esters Causes Meibomian Gland Dysfunction-Like Symptoms in aInternational journal of molecular sciences · 2021Article
- Deficiency in Acyl-CoA:Wax Alcohol Acyltransferase 2 causes evaporative dry eye disease by abolishing biosynthesis of wax esters.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- The prevalence of meibomian gland dysfunction, tear film and ocular surface parameters in an Austrian dry eye clinic population.Acta ophthalmologica · 2018Article
- Hyaluronan Regulates Eyelid and Meibomian Gland Morphogenesis.Investigative ophthalmology & visual science · 2018Article
- The function and morphology of Meibomian glands in patients with thyroid eye disease: a preliminary study.BMC ophthalmology · 2018Article
- Meibomian gland morphogenesis requires developmental eyelid closure and lid fusion.The ocular surface · 2017Article
- TFOS DEWS II Tear Film Report.The ocular surface · 2017Review
- Evaluation of dry eye and meibomian gland dysfunction with meibography in vitiligo.Eye (London, England) · 2017Observational
- Eyelid cleansing with ointment for obstructive meibomian gland dysfunction.Japanese journal of ophthalmology · 2017Article
- Dissecting lipid metabolism in meibomian glands of humans and mice: An integrative study reveals a network of metabolic reactions not duplicated in other tissues.Biochimica et biophysica acta · 2016Article
- Characterization of Rat Meibomian Gland Ion and Fluid Transport.Investigative ophthalmology & visual science · 2016Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Meibomian glands are large sebaceous glands that are located as separate gland strands in parallel arrangement within the tarsal plates of the eyelids. Their oily product (meibum) is secreted by a holocrine mechanism during which the secretory cells (meibocytes) are completely transformed into the meibum after synthesis and accumulation of lipids. After production in the gland acini, meibum is transported through the ductal system via the connecting duct (ductule) and the central duct towards the orifice at the free lid margin close to the inner lid border. The embryological development of the Meibomian glands takes place during the differentiation of the eyelids in the sealing phase of the eyelids. They are not directly associated with hair follicles but share important similarities in embryology, structure and keratinization potency with the cilia. Similar to the sebaceous glands Meibomian glands are regulated via sex hormones and androgens have a supporting function whereas estrogens act antagonistically. However, in contrast to other sebaceous glands they also have a distinct innervation, apart from sympathetic and sensory primarily by parasympathetic fibers that share the innervation pattern of the lacrimal glands. The anatomy, embryology and histology of the Meibomian glands are explained here, mainly with respect to humans, in an extensive review.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.