Evidence map›Paper›PMID 19855947›Full record

ReviewNeuromolecular medicine2010

Phospholipases A2 and inflammatory responses in the central nervous system.

Grace Y Sun, Phullara B Shelat, Michael B Jensen, Yan He, Albert Y Sun, Agnes Simonyi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuromolecular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 2 syntheses or guidelines pooled it, 197 citations in OpenAlex.

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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Grace Y SunDepartment of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO 65211, USA. sung@missouri.edu
Phullara B Shelat
Michael B Jensen
Yan He
Albert Y Sun
Agnes Simonyi
University of Missouri · US

Funding

PATHOGENESIS OF PHOSPHOLIPASES A2 IN ADP01AG018357 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI SUN, GRACE Y · 2001 to 2012
$10.4M
NIA NIH HHS P01 AG018357
6 · The paper itself

Abstract

Phospholipases A2 (PLA2s) belong to a superfamily of enzymes responsible for hydrolyzing the sn-2 fatty acids of membrane phospholipids. These enzymes are known to play multiple roles for maintenance of membrane phospholipid homeostasis and for production of a variety of lipid mediators. Over 20 different types of PLA2s are present in the mammalian cells, and in snake and bee venom. Despite their common function in hydrolyzing fatty acids of phospholipids, they are diversely encoded by a number of genes and express proteins that are regulated by different mechanisms. Recent studies have focused on the group IV calcium-dependent cytosolic cPLA2, the group VI calcium-independent iPLA2, and the group II small molecule secretory sPLA2. In the central nervous system (CNS), these PLA2s are distributed among neurons and glial cells. Although the physiological role of these PLA2s in regulating neural cell function has not yet been clearly elucidated, there is increasing evidence for their involvement in receptor signaling and transcriptional pathways that link oxidative events to inflammatory responses that underline many neurodegenerative diseases. Recent studies also reveal an important role of cPLA2 in modulating neuronal excitatory functions, sPLA2 in the inflammatory responses, and iPLA2 with childhood neurologic disorders associated with brain iron accumulation. The goal for this review is to better understand the structure and function of these PLA2s and to highlight specific types of PLA2s and their cross-talk mechanisms in these inflammatory responses under physiological and pathological conditions in the CNS.

Indexed as

Alzheimer DiseaseApoptosisBrain IschemiaCatalytic DomainCentral Nervous SystemCytosolHumansInflammationMemoryNADPH OxidasesNeurodegenerative DiseasesNeurogliaNeuronsp38 Mitogen-Activated Protein KinasesPhospholipases A2PhospholipidsNADPH Oxidasesp38 Mitogen-Activated Protein KinasesPhospholipases A2PhospholipidsReceptors, N-Methyl-D-AspartateRNA, Messenger

Identifiers

PMID19855947
PMCPMC3075861
OpenAlexW2010243434

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.