ArticleDevelopment (Cambridge, England)2009
The establishment of sexual identity in the Drosophila germline.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 55 citations in OpenAlex.
- Primordial Germ Cell Development in Teleosts: Their Origin, Fate and Role in Sex Determination.Stem cell reviews and reports · 2026Review
- Review
- Female germline expression of OVO transcription factor bridges Drosophila generations.G3 (Bethesda, Md.) · 2025Article
- Transient chromatin decompaction at the start ofLife science alliance · 2024Article
- Juvenile hormones direct primordial germ cell migration to the embryonic gonad.Current biology : CB · 2024Article
- Maternal Piwi regulates primordial germ cell development to ensure the fertility of female progeny in Drosophila.Genetics · 2021Article
- Trajectory mapping of the earlyGenome research · 2021Article
- Germline masculinization by Phf7 in D. melanogaster requires its evolutionarily novel C-terminus and the HP1-family protein HP1D3csd.Scientific reports · 2021Article
- Absence of X-chromosome dosage compensation in the primordial germ cells of Drosophila embryos.Scientific reports · 2021Article
- An autoregulatory switch in sex-specificDevelopment (Cambridge, England) · 2020Article
- Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation.Cell · 2019Article
- Doublesex controls specification and maintenance of the gonad stem cell niches inDevelopment (Cambridge, England) · 2019Article
- Chinmo prevents transformer alternative splicing to maintain male sex identity.PLoS genetics · 2018Article
- Germ cell tumors: Insights from the Drosophila ovary and the mouse testis.Molecular reproduction and development · 2017Review
- The Mitochondrial Lon Protease Is Required for Age-Specific and Sex-Specific Adaptation to Oxidative Stress.Current biology : CB · 2017Article
- Conserved role of Ovo in germline development in mouse and Drosophila.Scientific reports · 2017Article
- Maintenance of Drosophila germline stem cell sexual identity in oogenesis and tumorigenesis.Development (Cambridge, England) · 2015Article
- The evolving puzzle of autosomal versus Y-linked male determination in Musca domestica.G3 (Bethesda, Md.) · 2014Article
- An X-linked sex ratio distorter in Drosophila simulans that kills or incapacitates both noncarrier sperm and sons.G3 (Bethesda, Md.) · 2014Article
- BMP signaling and the maintenance of primordial germ cell identity in Drosophila embryos.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The establishment of sexual identity is a crucial step of germ cell development in sexually reproducing organisms. Sex determination in the germline is controlled differently than in the soma, and often depends on communication from the soma. To investigate how sexual identity is established in the Drosophila germline, we first conducted a molecular screen for genes expressed in a sex-specific manner in embryonic germ cells. Sex-specific expression of these genes is initiated at the time of gonad formation (stage 15), indicating that sexual identity in the germline is established by this time. Experiments where the sex of the soma was altered relative to that of the germline (by manipulating transformer) reveal a dominant role for the soma in regulating initial germline sexual identity. Germ cells largely take on the sex of the surrounding soma, although the sex chromosome constitution of the germ cells still plays some role at this time. The male soma signals to the germline through the JAK/STAT pathway, while the nature of the signal from the female soma remains unknown. We also find that the genes ovo and ovarian tumor (otu) are expressed in a female-specific manner in embryonic germ cells, consistent with their role in promoting female germline identity. However, removing the function of ovo and otu, or reducing germline function of Sex lethal, had little effect on establishment of germline sexual identity. This is consistent with our findings that signals from the soma are dominant over germline autonomous cues at the initial stage of germline sex determination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.