ArticleDevelopment (Cambridge, England)2009
Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expression.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
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- Single-cell sequencing unveils the impact of aging on the progenitor cell diversity in the telencephalon of the female killifish N. furzeri.Aging cell · 2024Article
- Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction ofInternational journal of molecular sciences · 2023Article
- Loss of zebrafish dzip1 results in inappropriate recruitment of periocular mesenchyme to the optic fissure and ocular coloboma.PloS one · 2022Article
- Loss of Active Neurogenesis in the Adult Shark Retina.Frontiers in cell and developmental biology · 2021Article
- Evidence for the temporal regulation of insect segmentation by a conserved sequence of transcription factors.Development (Cambridge, England) · 2018Article
- Toxicity implications for early life stage Japanese medaka (Oryzias latipes) exposed to oxyfluorfen.Environmental toxicology · 2018Article
- Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis.Developmental biology · 2017Article
- Novel roles for the radial spoke head protein 9 in neural and neurosensory cilia.Scientific reports · 2016Article
- Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- Development of astrocytes in the vertebrate eye.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle.Nature communications · 2014Article
- Ethanol alters gene expression and cell organization during optic vesicle evagination.Neuroscience · 2013Article
- Zebrafish Zic2a and Zic2b regulate neural crest and craniofacial development.Developmental biology · 2013Article
- Spatiotemporal expression of Zic genes during vertebrate inner ear development.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling.Development (Cambridge, England) · 2012Article
- Article
- Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway.PLoS genetics · 2012Article
- Toward a better understanding of human eye disease insights from the zebrafish, Danio rerio.Progress in molecular biology and translational science · 2011Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Holoprosencephaly (HPE) is the most common congenital malformation of the forebrain in human. Several genes with essential roles during forebrain development have been identified because they cause HPE when mutated. Among these are genes that encode the secreted growth factor Sonic hedgehog (Shh) and the transcription factors Six3 and Zic2. In the mouse, Six3 and Shh activate each other's transcription, but a role for Zic2 in this interaction has not been tested. We demonstrate that in zebrafish, as in mouse, Hh signaling activates transcription of six3b in the developing forebrain. zic2a is also activated by Hh signaling, and represses six3b non-cell-autonomously, i.e. outside of its own expression domain, probably through limiting Hh signaling. Zic2a repression of six3b is essential for the correct formation of the prethalamus. The diencephalon-derived optic stalk (OS) and neural retina are also patterned in response to Hh signaling. We show that zebrafish Zic2a limits transcription of the Hh targets pax2a and fgf8a in the OS and retina. The effects of Zic2a depletion in the forebrain and in the OS and retina are rescued by blocking Hh signaling or by increasing levels of the Hh antagonist Hhip, suggesting that in both tissues Zic2a acts to attenuate the effects of Hh signaling. These data uncover a novel, essential role for Zic2a as a modulator of Hh-activated gene expression in the developing forebrain and advance our understanding of a key gene regulatory network that, when disrupted, causes HPE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.