ReviewTrends in endocrinology and metabolism: TEM2010
Leptin receptor modulation of adiposity and fertility.
Review in Trends in endocrinology and metabolism: TEM, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 73 citations in OpenAlex.
- Leptin Receptor b (LEPRb) Mutations Disrupt Hypothalamic Control of the Reproductive Axis.International journal of molecular sciences · 2026Review
- Effects of Novel Mutations in theVeterinary sciences · 2025Article
- Evaluating regional heritability mapping methods for identifying QTLs in a wild population of Soay sheep.Heredity · 2025Article
- A Leptin Receptor Mutation Which Impairs Fertility in Ewes Causes Delayed Puberty in Male and Female Mice.Endocrinology · 2025Article
- Generation of LEPR Knockout Rabbits with CRISPR/CAS9 System.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2024Article
- The role of leptin and low testosterone in obesity.International journal of impotence research · 2022Review
- Genome-wide analyses reveal a strong association between LEPR gene variants and body fat reserves in ewes.BMC genomics · 2022Article
- Genome engineering and disease modelingWorld journal of stem cells · 2021Review
- TheAnimals : an open access journal from MDPI · 2020Article
- Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids.The Journal of biological chemistry · 2020Article
- Comparison of Serum Leptin Level in Women with Unexplained Infertility and Fertile Women in Iran.Journal of obstetrics and gynaecology of India · 2016Article
- Preliminary Characterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9 System.Scientific reports · 2015Article
- The Influence of LepR Tyrosine Site Mutations on Mouse Ovary Development and Related Gene Expression Changes.PloS one · 2015Article
- Article
- Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction.American journal of physiology. Endocrinology and metabolism · 2013Article
- ROCK1 in AgRP neurons regulates energy expenditure and locomotor activity in male mice.Endocrinology · 2013Article
- Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice.PLoS genetics · 2013Article
- Role of leptin receptor (LEPR) gene polymorphisms and haplotypes in susceptibility to hepatocellular carcinoma in subjects with chronic hepatitis B virus infection.Molecular diagnosis & therapy · 2012Article
- Effects of leptin and melanocortin signaling interactions on pubertal development and reproduction.Endocrinology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The leptin receptor was discovered as a leptin binding protein, which is highly expressed in the choroid plexus. Mapping of the gene's chromosomal locations in rodents revealed that mutations in Lepr were the basis of obesity/diabetes mutations in rodents and humans. Genetic manipulations that target Lepr expression in specific neurons or hypothalamic areas have generated insights into the modes by which body composition and reproductive function are modulated by the leptin receptor. These animal models have also been instrumental in identifying diabetes susceptibility genes. In this review we discuss the evidence that supports the concept of networked functions of leptin receptor as it pertains to feeding, substrate utilization and reproduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.