ArticleBiomaterials2010
Long-term biostability of self-assembling protein polymers in the absence of covalent crosslinking.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 84 citations in OpenAlex.
- Self-assembly in elastin-like recombinamers: a mechanism to mimic natural complexity.Materials today. Bio · 2019Review
- Amphiphilic peptides as novel nanomaterials: design, self-assembly and application.International journal of nanomedicine · 2018Review
- Optimizing Multiplexed Detections of Diabetes Antibodies via Quantitative Microfluidic Droplet Array.Small (Weinheim an der Bergstrasse, Germany) · 2017Article
- Microablation of collagen-based substrates for soft tissue engineering.Biomedical materials (Bristol, England) · 2014Article
- Acellular vascular grafts generated from collagen and elastin analogs.Acta biomaterialia · 2013Article
- Incorporation of fibronectin to enhance cytocompatibility in multilayer elastin-like protein scaffolds for tissue engineering.Journal of biomedical materials research. Part A · 2013Article
- Light-controlled graphene-elastin composite hydrogel actuators.Nano letters · 2013Article
- Hydrazone self-crosslinking of multiphase elastin-like block copolymer networks.Acta biomaterialia · 2012Article
- Maleimide-thiol coupling of a bioactive peptide to an elastin-like protein polymer.Acta biomaterialia · 2012Article
- Natural and Genetically Engineered Proteins for Tissue Engineering.Progress in polymer science · 2012Article
- Elastin-like protein matrix reinforced with collagen microfibers for soft tissue repair.Biomaterials · 2011Article
- Recombinant elastin-mimetic biomaterials: Emerging applications in medicine.Advanced drug delivery reviews · 2010Review
- The use of microfiber composites of elastin-like protein matrix reinforced with synthetic collagen in the design of vascular grafts.Biomaterials · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Unless chemically crosslinked, matrix proteins, such as collagen or silk, display a limited lifetime in vivo with significant degradation observed over a period of weeks. Likewise, amphiphilic peptides, lipopeptides, or glycolipids that self-assemble through hydrophobic interactions to form thin films, fiber networks, or vesicles do not demonstrate in vivo biostability beyond a few days. We report herein that a self-assembling, recombinant elastin-mimetic triblock copolymer elicited minimal inflammatory response and displayed robust in vivo stability for periods exceeding 1 year, in the absence of either chemical or ionic crosslinking. Specifically, neither a significant inflammatory response nor calcification was observed upon implantation of test materials into the peritoneal cavity or subcutaneous space of a mouse model. Moreover, serial quantitative magnetic resonance imaging, evaluation of pre- and post-explant ultrastructure by cryo-high resolution scanning electron microscopy, and an examination of implant mechanical responses revealed substantial preservation of form, material architecture, and biomechanical properties, providing convincing evidence of a non-chemically or ionically crosslinked protein polymer system that exhibits long-term stability in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.