SynthesisThe American journal of medicine2009
An umbrella review: corticosteroid therapy for adults with acute asthma.
Synthesis in The American journal of medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for acute asthma.The Cochrane database of systematic reviews · 2018Pooled it
- Different oral corticosteroid regimens for acute asthma.The Cochrane database of systematic reviews · 2016Pooled it
- Trial
- Inhaled magnesium versus inhaled salbutamol in rescue treatment for moderate and severe asthma exacerbations in pediatric patients.Jornal de pediatriaTrial
- Epidemiology and Immunopathogenesis of Virus Associated Asthma Exacerbations.Journal of asthma and allergy · 2023Review
- Oral corticosteroids stewardship for asthma in adults and adolescents: A position paper from the Thoracic Society of Australia and New Zealand.Respirology (Carlton, Vic.) · 2021Review
- Asthma in the Primary Care Setting.The Medical clinics of North America · 2019Review
- Semantic integration of clinical laboratory tests from electronic health records for deep phenotyping and biomarker discovery.NPJ digital medicine · 2019Article
- Critical asthma syndrome in the ICU.Clinical reviews in allergy & immunology · 2015Review
- Corticosteroids in the treatment of acute asthma.Annals of thoracic medicine · 2014Review
- A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function.Journal of cell science · 2013Article
- Differences between asthmatics and nonasthmatics hospitalised with influenza A infection.The European respiratory journal · 2013Article
- The patient with asthma in the emergency department.Clinical reviews in allergy & immunology · 2012Review
- Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- World allergy organization guidelines for the assessment and management of anaphylaxis.The World Allergy Organization journal · 2011Article
- Asthma Exacerbations: Pathogenesis, Prevention, and Treatment.The journal of allergy and clinical immunology. In practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
The objective of this "umbrella" review is to synthesize the evidence and provide clinicians a single report that summarizes the state of knowledge regarding the use of corticosteroids in adults with acute asthma. Systematic reviews in the Cochrane Library and additional clinical trials published in English from 1966 to 2007 in MEDLINE, EMBASE, CINAHL, and Cochrane CENTRAL, and references from bibliographies of pertinent articles were reviewed. Results indicate that the evidence base is frequently limited to small, single-center studies. Findings suggest that therapy with systemic corticosteroids accelerates the resolution of acute asthma and reduces the risk of relapse. There is no evidence that corticosteroid doses greater than standard doses (prednisone 50-100 mg equivalent) are beneficial. Oral and intravenous corticosteroids, as well as intramuscular and oral corticosteroid regimens, seem to be similarly effective. A nontapered 5- to 10-day course of corticosteroid therapy seems to be sufficient for most discharged patients. Combinations of oral and inhaled corticosteroids on emergency department/hospital discharge might minimize the risk of relapse.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.