Evidence map›Paper›PMID 19854099›Full record

ReviewCurrent opinion in microbiology2009

Signals of growth regulation in bacteria.

Christopher S Hayes, David A Low

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. RSC medicinal chemistry · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Deletion ofAntimicrobial agents and chemotherapy · 2021
    Article
  7. Adaptations ofFrontiers in microbiology · 2021
    Review
  8. Responses ofMicroorganisms · 2020
    Article
  9. Article
  10. Review
  11. Cancer across the tree of life: cooperation and cheating in multicellularity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. SecB-like chaperone controls a toxin-antitoxin stress-responsive system in Mycobacterium tuberculosis.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
  19. Article
  20. Exit from dormancy in microbial organisms.Nature reviews. Microbiology · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher S HayesDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
David A Low
University of California, Santa Barbara · US

Funding

Vaccines and Diagnostics TrialsU54AI065359 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARBOUR, ALAN G. · 2005 to 2013
$88.8M
Molecular determinants of A-site mRNA cleavage ribosomeR01GM078634 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI HAYES, CHRISTOPHER S. · 2006 to 2014
$2.5M
NIAID NIH HHS 1U54 AI065359NIAID NIH HHS U54 AI065359NIGMS NIH HHS GM078634NIGMS NIH HHS R01 GM078634
6 · The paper itself

Abstract

A fundamental characteristic of cells is their ability to regulate growth in response to changing environmental conditions. This review focuses on recent progress toward understanding the mechanisms by which bacterial growth is regulated. These phenomena include the 'viable but not culturable' (VBNC) state, in which bacterial growth becomes conditional, and 'persistence', which confers antibiotic resistance to a small fraction of bacteria in a population. Notably, at least one form of persistence appears to involve the generation of nongrowing phenotypic variants after transition through stationary phase. The possible roles of toxin-antitoxin modules in growth control are explored, as well as other mechanisms including contact-dependent growth inhibition, which regulates cellular metabolism and growth through binding to an outer membrane protein receptor.

Indexed as

Bacterial Physiological PhenomenaCell CycleGene Expression Regulation, BacterialSignal TransductionBacteriaBacterial ToxinsMicrobial ViabilityModels, BiologicalBacterial Toxins

Identifiers

PMID19854099
PMCPMC2789310
OpenAlexW2095449049

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.