ReviewTrends in endocrinology and metabolism: TEM2009
The molecular basis of hypopituitarism.
Review in Trends in endocrinology and metabolism: TEM, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05334563 (The Incidence of Congenital Combined Pituitary Hormone Deficiency in Denmark - a National Observational Study), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Incidence of Congenital Combined Pituitary Hormone Deficiency in Denmark - a National Observational Study
Who cites it
17 citing papers in PubMed, 67 citations in OpenAlex.
- Tracing the Evolution of Sex Hormones and Receptor-Mediated Immune Microenvironmental Differences in Prostate and Bladder Cancers: From Embryonic Development to Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A deep learning approach to predict differentiation outcomes in hypothalamic-pituitary organoids.Communications biology · 2024Article
- Commentary on "Clinical and genetic features of childhood-onset congenital combined pituitary hormone deficiency: a retrospective, single-center cohort study".Annals of pediatric endocrinology & metabolism · 2024Article
- Diagnosis and Incidence of Congenital Combined Pituitary Hormone Deficiency in Denmark-A National Observational Study.The Journal of clinical endocrinology and metabolism · 2023Observational
- Growth and Adult Height during Human Growth Hormone Treatment in Chinese Children with Multiple Pituitary Hormone Deficiency Caused by Pituitary Stalk Interruption Syndrome: A Single Centre StudyJournal of clinical research in pediatric endocrinology · 2020Article
- Genome-wide methylation study of whole blood cells DNA in men with congenital hypopituitarism disease.International journal of molecular medicine · 2019Article
- Extreme Short Stature and Severe Neurological Impairment in a 17-Year-Old Male With Untreated Combined Pituitary Hormone Deficiency Due toFrontiers in endocrinology · 2019Article
- Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells.Nature communications · 2016Article
- Molecular analysis of PROP1, POU1F1, LHX3, and HESX1 in Turkish patients with combined pituitary hormone deficiency: a multicenter study.Endocrine · 2015Article
- Dose-dependent dual role of PIT-1 (POU1F1) in somatolactotroph cell proliferation and apoptosis.PloS one · 2015Article
- Spreading the clinical window for diagnosing fetal-onset hypogonadism in boys.Frontiers in endocrinology · 2014Review
- Congenital adenohypophyseal hypoplasia associated with secondary hypothyroidism in a 2-week-old Portuguese water dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2012Article
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- The role of homeodomain transcription factors in heritable pituitary disease.Nature reviews. Endocrinology · 2011Review
- Pathogenesis of pituitary tumors.Nature reviews. Endocrinology · 2011Review
- GENETIC DISORDERS OF PITUITARY DEVELOPMENT IN PATIENTS WITH SHEEHAN'S SYNDROME.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Hypopituitarism is defined as the deficiency of one or more of the hormones secreted by the pituitary gland. Several developmental factors necessary for pituitary embryogenesis and hormone secretion have been described, and mutations of these genes in humans provide a molecular understanding of hypopituitarism. Genetic studies of affected patients and their families provide insights into possible mechanisms of abnormal pituitary development; however, mutations are rare. This review characterizes several of these developmental proteins and their role in the pathogenesis of hypopituitarism. Continuing research is required to better understand the complexities and interplay between these pituitary factors and to make improvements in genetic diagnosis that can lead to early detection and provide a future cure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.