Evidence map›Paper›PMID 19853831›Full record

ReviewBest practice & research. Clinical rheumatology2009

Juvenile dermatomyositis: new developments in pathogenesis, assessment and treatment.

Lucy R Wedderburn, Lisa G Rider

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Best practice & research. Clinical rheumatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02594735 (Abatacept for the Treatment of Refractory Juvenile Dermatomyositis), which is not on this map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02594735 phase4completednot on this mapstarted 2015, after this paper: background citation

Abatacept for the Treatment of Refractory Juvenile Dermatomyositis

TypeinterventionalSponsorGeorge Washington UniversityRan2015 to 2021Enrolled10ConditionsDermatomyositisArmsAbatacept
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 122 citations in OpenAlex.

  1. NMJ-associated transcriptomic remodeling correlates with disease severity in juvenile dermatomyositis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  2. Article
  3. Review
  4. Basic Investigations in Pediatric Rheumatology.Indian journal of pediatrics · 2024
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Treatment of Calcinosis in Juvenile Dermatomyositis.Current rheumatology reports · 2021
    Review
  12. Observational
  13. Article
  14. Article
  15. Article
  16. The Vasculopathy of Juvenile Dermatomyositis.Frontiers in pediatrics · 2018
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Lucy R WedderburnRheumatology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK. l.wedderburn@ich.ucl.ac.uk
Lisa G Rider
National Institute of Environmental Health Sciences · USUniversity College London · GB

Funding

Environmental/genetic Risk Factors and Pathogenesis of Autoimmune DiseaseZIAES101074 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RIDER, LISA · 2009 to 2025
$34.6M
Assessment, Therapy and Prevention Of Autoimmune DiseaseZIAES101081 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RIDER, LISA · 2009 to 2025
$17.6M
Pathogenesis And Genetic/environmental Risk Factors ForZ01ES101074 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MILLER, FREDERICK · 2002 to 2008
$2.7M
Assessment, Therapy and Prevention Of Autoimmune DiseaseZ01ES101081 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MILLER, FREDERICK · 2002 to 2008
$2.2M
Intramural NIH HHS Z01 ES101074Intramural NIH HHS Z01 ES101081Wellcome Trust
6 · The paper itself

Abstract

Juvenile dermatomyositis (JDM) is a rare, potentially life-threatening systemic autoimmune disease primarily affecting muscle and skin. Recent advances in the recognition, standardised assessment and treatment of JDM have been greatly facilitated by large collaborative research networks. Through these networks, a number of immunogenetic risk factors have now been defined, as well as a number of potential pathways identified in the aetio-pathogenesis of JDM. Myositis-associated and myositis-specific autoantibodies are helping to sub-phenotype JDM, defined by clinical features, outcomes and immunogenetic risk factors. Partially validated tools to assess disease activity and damage have assisted in standardising outcomes. Aggressive treatment approaches, including multiple initial therapies, as well as new drugs and biological therapies for refractory disease, offer promise of improved outcomes and less corticosteroid-related toxicity.

Indexed as

DermatomyositisAutoantibodiesChildDose-Response Relationship, DrugDrug Therapy, CombinationGlucocorticoidsHumansImmunosuppressive AgentsAutoantibodiesGlucocorticoidsImmunosuppressive Agents

Identifiers

PMID19853831
PMCPMC2774891
OpenAlexW1981069139

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.