ArticleNeuroImage2010
Effective connectivity of neural networks in automatic movements in Parkinson's disease.
Article in NeuroImage, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of motor-cognitive training on dual-task performance in people with Parkinson's disease: a systematic review and meta-analysis.Journal of neurology · 2023Pooled it
- Attentional focus effect on dual-task walking in Parkinson's disease with and without freezing of gait.GeroScience · 2023Trial
- Protocol for a randomized comparison of integrated versus consecutive dual task practice in Parkinson's disease: the DUALITY trial.BMC neurology · 2014Trial
- Cerebellar Perfusion Changes After Repetitive Deep Transcranial Magnetic Stimulation in Parkinson's Disease: A Five-Patient Case Series and Literature Review.Diagnostics (Basel, Switzerland) · 2026Article
- Brain Connectivity, Neural Networks, and Resilience in Aging and Neurodegeneration.The American journal of pathology · 2025Review
- Progressive Changes Between Thalamic Nuclei and Cortical Networks Across Stimulus-Response Learning.Human brain mapping · 2025Article
- Dynamic Task-Related Changes in Electroencephalography Brain Connectivity During a Button-Press Task in Children with and Without Bilateral Cerebral Palsy.Brain connectivity · 2025Article
- "Dance Well"-A Multisensory Artistic Dance Intervention for People with Parkinson's Disease: A Pilot Study.Brain sciences · 2025Article
- Connecting Auditory-Perceptual Prompts Used in Voice Therapy to Anatomy and Physiology: Application to the Estill Voice Model and the Rehabilitation Treatment Specification System.Journal of voice : official journal of the Voice Foundation · 2024Article
- Sensorimotor Network Segregation Predicts Long-Term Learning of Writing Skills in Parkinson's Disease.Brain sciences · 2024Article
- High-dimensional multisubject time series transition matrix inference with application to brain connectivity analysis.Biometrics · 2024Article
- Daily Habits in Parkinson's Disease: Validation of the Daily Habit Scale.Movement disorders clinical practice · 2023Article
- Goal-directed and habitual control: from circuits and functions to exercise-induced neuroplasticity targets for the treatment of Parkinson's disease.Frontiers in neurology · 2023Review
- Respiratory Responses to Two Voice Interventions for Parkinson's Disease.Journal of speech, language, and hearing research : JSLHR · 2022Article
- Associations between resting-state functional connectivity changes and prolonged benefits of writing training in Parkinson's disease.Journal of neurology · 2022Article
- Effects of task prioritization on a postural-motor task in early-stage Parkinson's disease: EEG connectivity and clinical implication.GeroScience · 2022Article
- Discussion of Research Priorities for Gait Disorders in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Review
- Topological patterns of motor networks in Parkinson's disease with different sides of onset: A resting-state-informed structural connectome study.Frontiers in aging neuroscience · 2022Article
- The Supplementary Motor Complex in Parkinson's Disease.Journal of movement disorders · 2022Article
- Motor Sequence Learning Deficits in Idiopathic Parkinson's Disease Are Associated With Increased Substantia Nigra Activity.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Patients with Parkinson's disease (PD) have difficulty in performing learned movements automatically. The neural mechanism of this deficiency remains unclear. In the current study, we used functional MRI (fMRI) and psychophysiological interaction (PPI) methods to investigate the changes in effective connectivity of the brain networks when movements become automatic in PD patients and age-matched normal controls. We found that during automaticity, the rostral supplementary motor area, cerebellum, and cingulate motor area had increased effective connectivity with brain networks in PD patients. In controls, in addition to these regions, the putamen also had automaticity-related strengthened interactions with brain networks. The dorsal lateral prefrontal cortex had more connectivity at the novel stage than in the automatic stage in normal subjects, but not in PD patients. The comparison of the PPI results between the groups showed that the rostral supplementary motor area, cerebellum, and cingulate motor area had significantly more increased effective connectivity with several regions in normal subjects than in PD. The changes of effective connectivity in some areas negatively correlated with the Unified Parkinson's Disease Rating Scale (UPDRS). Our findings show that some of the factors related to PD patients having difficulty achieving automaticity are less efficient neural coding of movement and failure to shift execution of automatic movements more subcortically. The changes of effective connectivity become more abnormal as the disorder progresses. In addition, in PD, the connections of the attentional networks are altered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.