ArticleThe journal of pain2010
Pain catastrophizing and salivary cortisol responses to laboratory pain testing in temporomandibular disorder and healthy participants.
Article in The journal of pain, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Complementary and integrative health approaches to manage chronic pain in U.S. military populations: Results from a systematic review and meta-analysis, 1985-2019.Psychological services · 2021Pooled it
- Virtual Reality Distraction vs Nitrous Oxide for Reducing Anxiety and Injection Pain.Anesthesia progress · 2025Trial
- Psychobiological response to pain in female adolescents with nonsuicidal self-injury.Journal of psychiatry & neuroscience : JPN · 2017Trial
- Autonomic nervous system and hypothalamic-pituitary-adrenal axis response to experimentally induced cold pain in adolescent non-suicidal self-injury--study protocol.BMC psychiatry · 2015Trial
- The Impact of Catastrophization and Emotions on Pain: A Narrative Review of Underlying Mechanisms.Journal of pain research · 2026Review
- The Potential of a Robot Presence in Close Relationship to Influence Human Responses to Experimental Pain.Life (Basel, Switzerland) · 2025Article
- Tell me what to expect: how instructions affect the pain response of patients with chronic myofascial pain with referral.Journal of oral & facial pain and headache · 2024Article
- Is There a Relationship between Salivary Cortisol and Temporomandibular Disorder: A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- This pain drives me crazy: Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome.World journal of psychiatry · 2024Article
- Examining Reactivity and Recovery Patterns of Pain-Evoked Cortisol and Alpha-Amylase Trajectories: Relations Between Psychological Markers of Risk and Resilience.The journal of pain · 2024Article
- Effect of Intravenous Dexamethasone Dose on the Occurrence of Rebound Pain after Axillary Plexus Block in Ambulatory Surgery.Journal of clinical medicine · 2023Article
- Association of Academic Stress, Acne Symptoms and Other Physical Symptoms in Medical Students of King Khalid University.International journal of environmental research and public health · 2022Article
- Serum Concentrations of the Endocannabinoid, 2-Arachidonoylglycerol, in the Peri-Trauma Period Are Positively Associated with Chronic Pain Months Later.Biomedicines · 2022Article
- Sciatic nerve injury rebalances the hypothalamic-pituitary-adrenal axis in rats with persistent changes to their social behaviours.Journal of neuroendocrinology · 2022Article
- Predisposing factors for increased cortisol levels in oral cancer patients.Comprehensive psychoneuroendocrinology · 2022Article
- Adverse Impacts of Temporomandibular Disorders Symptoms and Tooth Loss on Psychological States and Oral Health-Related Quality of Life During the COVID-19 Pandemic Lockdown.Frontiers in public health · 2022Article
- Psycho-sensory relationships in chronic pain.British journal of pain · 2021Article
- Mindful Nonreactivity Moderates the Relationship between Chronic Stress and Pain Interference in Law Enforcement Officers.Journal of police and criminal psychology · 2021Article
- What Does CATS Have to Do With Cancer? The Cognitive Activation Theory of Stress (CATS) Forms the SURGE Model of Chronic Post-surgical Pain in Women With Breast Cancer.Frontiers in psychology · 2021Review
- The Effects Induced by Spinal Manipulative Therapy on the Immune and Endocrine Systems.Medicina (Kaunas, Lithuania) · 2019Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledPain catastrophizing is an important variable in the context of acute and chronic pain. The neurophysiological correlates of pain catastrophizing, however, have not been rigorously evaluated. We examined the relationship between trait-pain catastrophizing and morning salivary cortisol levels before and following a 45-minute laboratory pain-testing session in healthy, pain-free (n = 22), and temporomandibular disorder (TMD) participants (n = 39). We also examined whether TMD patients evidenced generalized hyperalgesia and hypercortisolism. Pain catastrophizing was associated with a flattened morning salivary cortisol profile in the context of pain testing, irrespective of pain status. Cortisol profiles did not differ between healthy and TMD participants. TMD was associated with mechanical hyperalgesia only at the masseter. These data are the first to show an association between pain catastrophizing and elevated salivary cortisol profiles in the context of standardized experimental pain testing. These findings in both healthy individuals and those with chronic orofacial pain suggest that aberrant adrenocortical responses to pain may serve as a neurophysiologic pathway by which pain catastrophizing enhances vulnerability for development of chronic pain and maintains and/or exaggerates existing pain and associated morbidity. PERSPECTIVE: Neurophysiological mechanisms by which pain catastrophizing is related to acute and chronic pain recently have come under empirical study. Understanding of these mechanisms has the unique potential to shed light on key central-nervous-system factors that mediate catastrophizing-pain relations and therapeutic benefits associated with changes in catastrophizing and related cognitive processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.