ArticleCurrent biology : CB2009
The C. elegans dosage compensation complex propagates dynamically and independently of X chromosome sequence.
Article in Current biology : CB, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 52 citations in OpenAlex.
- Condensin IDC has a functional ATPase that is required for X-Chromosome dosage compensation in C. elegans.Genetics · 2026Article
- Sex-specific transcriptome dynamics ofGenes & development · 2025Article
- XOL-1 regulates developmental timing by modulating the H3K9 landscape in C. elegans early embryos.PLoS genetics · 2024Article
- Chromatin Organization duringDNA · 2024Article
- Topoisomerases I and II facilitate condensin DC translocation to organize and repress X chromosomes in C. elegans.Molecular cell · 2022Article
- Article
- Karyotype engineering reveals spatio-temporal control of replication firing and gene contacts.Cell genomics · 2022Article
- Review
- The histone H4 lysine 20 demethylase DPY-21 regulates the dynamics of condensin DC binding.Journal of cell science · 2022Article
- Binding of anGenetics · 2019Article
- In Vivo Evidence for ATPase-Dependent DNA Translocation by the Bacillus subtilis SMC Condensin Complex.Molecular cell · 2018Article
- Caenorhabditis elegans Dosage Compensation: Insights into Condensin-Mediated Gene Regulation.Trends in genetics : TIG · 2018Review
- Article
- Article
- Developmental Dynamics of X-Chromosome Dosage Compensation by the DCC and H4K20me1 in C. elegans.PLoS genetics · 2015Article
- Linking dosage compensation and X chromosome nuclear organization in C. elegans.Nucleus (Austin, Tex.) · 2015Article
- Mechanisms of x chromosome dosage compensation.Journal of genomics · 2015Review
- Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans.Genes & development · 2014Article
- Regulation of the X chromosomes in Caenorhabditis elegans.Cold Spring Harbor perspectives in biology · 2014Review
- Genome-wide analysis links emerin to neuromuscular junction activity in Caenorhabditis elegans.Genome biology · 2014Article
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3 authors at 1 institution in 1 country.
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Abstract
backgroundThe C. elegans dosage compensation complex (DCC) associates with both X chromosomes of XX animals to reduce X-linked transcript levels. Five DCC members are homologous to subunits of the evolutionarily conserved condensin complex, and two noncondensin subunits are required for DCC recruitment to X.
resultsWe investigated the molecular mechanism of DCC recruitment and spreading along X by examining gene expression and the binding patterns of DCC subunits in different stages of development, and in strains harboring X;autosome (X;A) fusions. We show that DCC binding is dynamically specified according to gene activity during development and that the mechanism of DCC spreading is independent of X chromosome DNA sequence. Accordingly, in X;A fusion strains, DCC binding propagates from X-linked recruitment sites onto autosomal promoters as a function of distance. Quantitative analysis of spreading suggests that the condensin-like subunits spread from recruitment sites to promoters more readily than subunits involved in initial X targeting.
conclusionsA highly conserved chromatin complex is appropriated to accomplish domain-scale transcriptional regulation during C. elegans development. Unlike X recognition, which is specified partly by DNA sequence, spreading is sequence independent and coupled to transcriptional activity. Similarities to the X recognition and spreading strategies used by the Drosophila DCC suggest mechanisms fundamental to chromosome-scale gene regulation.
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