ReviewProgress in neurobiology2010
Studies on the hippocampal formation: From basic development to clinical applications: Studies on schizophrenia.
Review in Progress in neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Modulation of spatial memory and expression of hippocampal neurotransmitter receptors by selective lesion of medial septal cholinergic and GABAergic neurons.Experimental brain research · 2020Article
- Modeling Psychiatric Disorder Biology with Stem Cells.Current psychiatry reports · 2020Review
- Modeling neuropsychiatric disorders using human induced pluripotent stem cells.Protein & cell · 2020Review
- Electroconvulsive therapy-induced brain functional connectivity predicts therapeutic efficacy in patients with schizophrenia: a multivariate pattern recognition study.NPJ schizophrenia · 2017Article
- Long-lasting changes in neural networks to compensate for altered nicotinic input.Biochemical pharmacology · 2015Review
- The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus.Biochemical pharmacology · 2015Review
- The novel α7 nicotinic acetylcholine receptor agonist EVP-6124 enhances dopamine, acetylcholine, and glutamate efflux in rat cortex and nucleus accumbens.Psychopharmacology · 2014Article
- Cortical parvalbumin GABAergic deficits with α7 nicotinic acetylcholine receptor deletion: implications for schizophrenia.Molecular and cellular neurosciences · 2014Article
- Article
- Hippocampal shape abnormalities of patients with childhood-onset schizophrenia and their unaffected siblings.Journal of the American Academy of Child and Adolescent Psychiatry · 2013Article
- Fragmentation and unpredictability of early-life experience in mental disorders.The American journal of psychiatry · 2012Review
- Medial temporal lobe structure and cognition in individuals with schizophrenia and in their non-psychotic siblings.Schizophrenia research · 2012Article
- Regulation of GABAergic inputs to CA1 pyramidal neurons by nicotinic receptors and kynurenic acid.The Journal of pharmacology and experimental therapeutics · 2012Article
- Cortical thickness, gray matter volume, and white matter anisotropy and diffusivity in schizophrenia.Neuroradiology · 2011Article
- Endogenous activation of nAChRs and NMDA receptors contributes to the excitability of CA1 stratum radiatum interneurons in rat hippocampal slices: effects of kynurenic acid.Biochemical pharmacology · 2011Article
- No association between polymorphisms of WNT2 and schizophrenia in a Korean population.BMC medical genetics · 2010Article
- Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.Dialogues in clinical neuroscience · 2010Review
- The human-specific duplicated α7 gene inhibits the ancestral α7, negatively regulating nicotinic acetylcholine receptor-mediated transmitter release.The Journal of biological chemistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The hippocampal formation plays a critical role in cognitive function. The developmental events that shape the hippocampal formation are continuing to be elucidated and their implications for brain function are emerging as well as applying those advances to interventions that have important possibilities for the treatment of brain dysfunction. The story told in this chapter is about the use of the in oculo transplant method to illuminate intrinsic and extrinsic features that underlie the development of the dentate gyrus and adjacent hippocampus and the role of one molecule in the hippocampus and schizophrenia. Schizophrenia, originally conceptualized as a dysfunction in dopaminergic neurotransmission, is now known to involve multiple neuronal systems. Dysfunction of hippocampal neurons is emerging as one of its signature pathological features. Basic insights into the development and function of hippocampal interneurons form the basis of a new treatment initiative for this illness. Evidence for the role of the alpha 7-nicotinic acetylcholine receptor in the development and function of these neurons in rodents has led to human trials of nicotinic agonists for cognitive dysfunction in schizophrenia and the possibility of improving hippocampal development in children at risk for schizophrenia by perinatal supplementation with choline, which can act as an alpha 7-nicotinic acetylcholine receptor agonist.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.