ArticleBMC medical genetics2009
Suggestive linkage detected for blood pressure related traits on 2q and 22q in the population on the Samoan islands.
Article in BMC medical genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- A stop-gain variant inHGG advances · 2023Pooled it
- Genome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels.Journal of human genetics · 2021Article
- A missense variant in CREBRF is associated with taller stature in Samoans.American journal of human biology : the official journal of the Human Biology Council · 2020Article
- Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.PloS one · 2013Article
- Epigenetics, and human biology and health responses to modernization in the Samoan archipelago.Collegium antropologicum · 2012Article
- Severe intellectual disability, omphalocele, hypospadia and high blood pressure associated to a deletion at 2q22.1q22.3: case report.Molecular cytogenetics · 2012Article
- Defining a rat blood pressure quantitative trait locus to a <81.8 kb congenic segment: comprehensive sequencing and renal transcriptome analysis.Physiological genomics · 2010Article
- Prevalence of adiposity and associated cardiometabolic risk factors in the Samoan genome-wide association study.American journal of human biology : the official journal of the Human Biology CouncilArticle
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundHigh blood pressure or hypertension is a major risk factor involved in the development of cardiovascular diseases. We conducted genome-wide variance component linkage analyses to search for loci influencing five blood pressure related traits including the quantitative traits systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP), the dichotomous trait hypertension (HT) and the bivariate quantitative trait SBP-DBP in families residing in American Samoa and Samoa, as well as in the combined sample from the two polities. We adjusted the traits for a number of environmental covariates such as smoking, alcohol consumption, physical activity and material life style.
resultsWe found suggestive univariate linkage for SBP on chromosome 2q35-q37 (LOD 2.4) and for PP on chromosome 22q13 (LOD 2.2), two chromosomal regions that recently have been associated with SBP and PP, respectively.
conclusionWe have detected additional evidence for a recently reported locus associated with SBP on chromosome 2q and a susceptibility locus for PP on chromosome 22q. However, differences observed between the results from our three partly overlapping genetically homogenous study samples from the Samoan islands suggest that additional studies should be performed in order to verify these results.
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