ArticleMolecular and cellular biochemistry2010
Ectopic expression of hC/EBPs in breast tumor cells induces apoptosis.
Article in Molecular and cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPβ.Oncotarget · 2015Article
- Transcriptional regulation prediction of antiestrogen resistance in breast cancer based on RNA polymerase II binding data.BMC bioinformatics · 2014Article
- E3 ubiquitin ligase E6AP negatively regulates adipogenesis by downregulating proadipogenic factor C/EBPalpha.PloS one · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
CCAAT/enhancer binding proteins (C/EBPs) are a group of transcription factors which have been implicated in cellular proliferation, terminal differentiation, and apoptosis in a variety of tissues including mammary gland. Owing to its role in various cellular functions, inactivation of C/EBP proteins is central to the pathogenesis of many disorders. Recent reports suggest that expression as well as function of C/EBP proteins is deregulated in breast tumors. Although, role of C/EBPs in growth arrest in mammary tissues has been studied in much detail; their role in apoptosis is relatively less explored. In the present study, we have assessed if breast tumors evade apoptosis and grow faster by down regulating and inhibiting the C/EBP proteins, C/EBPalpha in particular. Our data shows that ectopic expression of human C/EBPs in breast tumor cells inhibits proliferation and induces apoptosis which is likely to be associated with caspase dependent pathway.
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