ArticleCerebellum (London, England)2010
Predictive motor timing performance dissociates between early diseases of the cerebellum and Parkinson's disease.
Article in Cerebellum (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Is the cerebellum a potential target for stimulation in Parkinson's disease? Results of 1-Hz rTMS on upper limb motor tasks.Cerebellum (London, England) · 2011Trial
- Maternal Infection Impairs Motor Coordination in an Experimental Meningitis Rat Model Through Altered MMP-2/3/9 Activity, H3K4 Trimethylation, andInternational journal of molecular sciences · 2026Article
- A Pilot Study of Adolescents with Psychotic Experiences: Potential Cerebellar Circuitry Disruption Early Along the Psychosis Spectrum.Cerebellum (London, England) · 2024Article
- Perceptual influence of auditory pitch on motion speed.Journal of vision · 2021Article
- Modulation of cerebellar brain inhibition during temporal adaptive learning in a coincident timing task.Experimental brain research · 2021Article
- Pallidal Activity in Cervical Dystonia with and Without Head Tremor.Cerebellum (London, England) · 2020Article
- Quantitative but Not Qualitative Performance Changes in Predictive Motor Timing as a Result of Overtraining.Cerebellum (London, England) · 2020Article
- Cerebellar Cortex 4-12 Hz Oscillations and Unit Phase Relation in the Awake Rat.Frontiers in systems neuroscience · 2020Article
- Cerebellum, Basal Ganglia, and Cortex Mediate Performance of an Aerial Pursuit Task.Frontiers in human neuroscience · 2020Article
- Essential tremor: the most common form of cerebellar degeneration?Cerebellum & ataxias · 2020Review
- Graph theory analysis of resting-state functional magnetic resonance imaging in essential tremor.Human brain mapping · 2019Article
- Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications.Cerebellum (London, England) · 2019Article
- Essential tremor severity and anatomical changes in brain areas controlling movement sequencing.Annals of clinical and translational neurology · 2019Article
- Double dissociation of single-interval and rhythmic temporal prediction in cerebellar degeneration and Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The difference in visuomotor feedback velocity control during spiral drawing between Parkinson's disease and essential tremor.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Heterotopic Purkinje Cells: a Comparative Postmortem Study of Essential Tremor and Spinocerebellar Ataxias 1, 2, 3, and 6.Cerebellum (London, England) · 2018Article
- The mystery of the cerebellum: clues from experimental and clinical observations.Cerebellum & ataxias · 2018Review
- Cerebellar Pathology in Familial vs. Sporadic Essential Tremor.Cerebellum (London, England) · 2017Article
- Cerebellar Pathology in Early Onset and Late Onset Essential Tremor.Cerebellum (London, England) · 2017Article
- Linking Essential Tremor to the Cerebellum: Physiological Evidence.Cerebellum (London, England) · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is evidence that both the basal ganglia and the cerebellum play a role in the neural representation of time in a variety of behaviours, but whether one of them is more important is not yet clear. To address this question in the context of predictive motor timing, we tested patients with various movement disorders implicating these two structures in a motor-timing task. Specifically, we investigated four different groups: (1) patients with early Parkinson's disease (PD); (2) patients with sporadic spinocerebellar ataxia (SCA); (3) patients with familial essential tremor (ET); and (4) matched healthy controls. We used a predictive motor-timing task that involved mediated interception of a moving target, and we assessed the effect of movement type (acceleration, deceleration and constant), speed (slow, medium and fast) and angle (0 degrees , 15 degrees and 30 degrees) on performance (hit, early error and late error). The main results showed that PD group and arm ET subgroup did not significantly differ from the control group. SCA and head ET subjects (severe and mild cerebellar damage, respectively) were significantly worse at interception than the other two groups. Our findings support the idea that the basal ganglia play a less significant role in predictive motor timing than the cerebellum. The fact that SCA and ET subjects seemed to have a fundamental problem with predictive motor timing suggests that the cerebellum plays an essential role in integrating incoming visual information with the motor output in a timely manner, and that ET is a heterogeneous entity that deserves increased attention from clinicians.
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Registered trials
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