ArticleInvertebrate neuroscience : IN2009
Glutamatergic and GABAergic effects of fipronil on olfactory learning and memory in the honeybee.
Article in Invertebrate neuroscience : IN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- Never underestimate honeybees: Their exceptionally diverse adaptive strategies.Journal of advanced research · 2026Review
- Oral administration of phytochemicals protects honey bees against cognitive and motor impairments induced by the insecticide fipronil.PloS one · 2024Article
- The flavonoid rutin protects the bumble bee Bombus impatiens against cognitive impairment by imidacloprid and fipronil.The Journal of experimental biology · 2022Article
- Prey contaminated with neonicotinoids induces feeding deterrent behavior of a common farmland spider.Scientific reports · 2019Article
- Thymol Affects Congruency Between Olfactory and Gustatory Stimuli in Bees.Scientific reports · 2019Article
- Quantifying the impact of pesticides on learning and memory in bees.The Journal of applied ecology · 2018Article
- Genome-Wide Identification, Characterization and Expression Analysis of the Solute Carrier 6 Gene Family in Silkworm (Bombyx mori).International journal of molecular sciences · 2016Article
- Effect of a thymol application on olfactory memory and gene expression levels in the brain of the honeybee Apis mellifera.Environmental science and pollution research international · 2015Article
- The genomes of two key bumblebee species with primitive eusocial organization.Genome biology · 2015Article
- Effects of neonicotinoids and fipronil on non-target invertebrates.Environmental science and pollution research international · 2015Review
- Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment.Genome biology · 2014Article
- Article
- Scientific Opinion on the science behind the development of a risk assessment of Plant Protection Products on bees (EFSA journal. European Food Safety Authority · 2012Article
- Detection of pesticides in active and depopulated beehives in Uruguay.International journal of environmental research and public health · 2011Article
- Honeybee tracking with microchips: a new methodology to measure the effects of pesticides.Ecotoxicology (London, England) · 2011Article
- Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function.Advances in nutrition (Bethesda, Md.) · 2011Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated here the role of transmissions mediated by GABA and glutamate-gated chloride channels (GluCls) in olfactory learning and memory in honeybees, both of these channels being a target for fipronil. To do so, we combined olfactory conditioning with injections of either the GABA- and glutamate-interfering fipronil alone, or in combination with the blocker of glutamate transporter L-trans-Pyrrolidine-2,4-Dicarboxylicacid (L-trans-PDC), or the GABA analog Trans-4-Aminocrotonic Acid (TACA). Our results show that a low dose of fipronil (0.1 ng/bee) impaired olfactory memory, while a higher dose (0.5 ng/bee) had no effect. The detrimental effect induced by the low dose of fipronil was rescued by the coinjection of L-trans-PDC but was rather increased by the coinjection of TACA. Moreover, using whole-cell patch-clamp recordings, we observed that L-trans-PDC reduced glutamate-induced chloride currents in antennal lobe cells. We interpret these results as reflecting the involvement of both GluCl and GABA receptors in the impairment of olfactory memory induced by fipronil.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.