ArticlePLoS computational biology2009
A model of cardiovascular disease giving a plausible mechanism for the effect of fractionated low-dose ionizing radiation exposure.
Article in PLoS computational biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Ionising radiation and cardiovascular disease: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2023Pooled it
- Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks.Environmental health perspectives · 2012Pooled it
- Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms.Radiation and environmental biophysics · 2010Pooled it
- Radiation and circulatory disease.Mutation research. Reviews in mutation researchPooled it
- Long-Term Trends and Prognosis in Cardiovascular Mortality in the Kazakhstani Population Living Around the Semipalatinsk Nuclear Test Site.International journal of environmental research and public health · 2026Article
- Meta-Analysis of the Impact of Low-Dose Ionizing Radiation on Mortality and Progression of Heart Disease in the General Patient Population: Insights from Hormesis Theory in Cardiology.Journal of clinical medicine · 2024Review
- Revisiting an Inverse Dose-Fractionation Effect of Ionizing Radiation Exposure for Ischemic Heart Disease: Insights from Recent Studies.Radiation research · 2024Review
- Updated Estimates of Radiation Risk for Cancer and Cardiovascular Disease: Implications for Cardiology Practice.Journal of clinical medicine · 2024Review
- A Lipid-Structured Model of Atherosclerotic Plaque Macrophages with Lipid-Dependent Kinetics.Bulletin of mathematical biology · 2023Article
- The Evidence for Excess Risk of Cancer and Non-Cancer Disease at Low Doses and Dose Rates.Radiation research · 2022Article
- Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology.International journal of radiation biology · 2021Review
- Article
- Prevention of radiotherapy-induced arterial inflammation by interleukin-1 blockade.European heart journal · 2019Article
- Role of Ionizing Radiation in Neurodegenerative Diseases.Frontiers in aging neuroscience · 2018Review
- A mechanistic model for atherosclerosis and its application to the cohort of Mayak workers.PloS one · 2017Article
- Rays Sting: The Acute Cellular Effects of Ionizing Radiation Exposure.Translational medicine @ UniSa · 2016Article
- Circulatory disease mortality in the Massachusetts tuberculosis fluoroscopy cohort study.European journal of epidemiology · 2016Article
- Bifurcation and dynamics in a mathematical model of early atherosclerosis: How acute inflammation drives lesion development.Journal of mathematical biology · 2015Article
- Low dose radiation and circulatory diseases: a brief narrative review.Cardio-oncology (London, England) · 2015Review
- Acceleration of atherogenesis in ApoE-/- mice exposed to acute or low-dose-rate ionizing radiation.Oncotarget · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis is the main cause of coronary heart disease and stroke, the two major causes of death in developed society. There is emerging evidence of excess risk of cardiovascular disease at low radiation doses in various occupationally exposed groups receiving small daily radiation doses. Assuming that they are causal, the mechanisms for effects of chronic fractionated radiation exposures on cardiovascular disease are unclear. We outline a spatial reaction-diffusion model for atherosclerosis and perform stability analysis, based wherever possible on human data. We show that a predicted consequence of multiple small radiation doses is to cause mean chemo-attractant (MCP-1) concentration to increase linearly with cumulative dose. The main driver for the increase in MCP-1 is monocyte death, and consequent reduction in MCP-1 degradation. The radiation-induced risks predicted by the model are quantitatively consistent with those observed in a number of occupationally-exposed groups. The changes in equilibrium MCP-1 concentrations with low density lipoprotein cholesterol concentration are also consistent with experimental and epidemiologic data. This proposed mechanism would be experimentally testable. If true, it also has substantive implications for radiological protection, which at present does not take cardiovascular disease into account. The Japanese A-bomb survivor data implies that cardiovascular disease and cancer mortality contribute similarly to radiogenic risk. The major uncertainty in assessing the low-dose risk of cardiovascular disease is the shape of the dose response relationship, which is unclear in the Japanese data. The analysis of the present paper suggests that linear extrapolation would be appropriate for this endpoint.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.