Evidence map›Paper›PMID 19851336›Full record

ReviewNature reviews. Molecular cell biology2009

Non-muscle myosin II takes centre stage in cell adhesion and migration.

Miguel Vicente-Manzanares, Xuefei Ma, Robert S Adelstein, Alan Rick Horwitz

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,186 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,186citing papers in PubMed, 1 pooled it
38.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,186 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,989 citations in OpenAlex.

  1. Pooled it
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  12. Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026
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1,126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Miguel Vicente-ManzanaresDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA. miguelvix@virginia.edu
Xuefei Ma
Robert S Adelstein
Alan Rick Horwitz
University of Virginia · USNational Heart Lung and Blood Institute · USNational Institutes of Health · US

Funding

STRUCTUREU54GM064346 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI IMPERIALI, BARBARA · 2001 to 2010
$74.9M
DETERMINANTS OF MYOGENIC MEMBRANE PHENOMENAR01GM023244 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HORWITZ, ALAN F. "RICK" · 1985 to 2014
$6.7M
The Role of Nonmuscle Myosin II in CytokinesisZIAHL004228 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ADELSTEIN, ROBERT · 2009 to 2019
$5.0M
DETERMINANTS OF MYOGENIC MEMBRANE PHENOMENAR37GM023244 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HORWITZ, ALAN F · 1992 to 2002
$1.1M
Intramural NIH HHSNIGMS NIH HHS GM23244NIGMS NIH HHS R01 GM023244NIGMS NIH HHS R37 GM023244NIGMS NIH HHS U54 GM064346NIGMS NIH HHS U54-GM064346
6 · The paper itself

Abstract

Non-muscle myosin II (NM II) is an actin-binding protein that has actin cross-linking and contractile properties and is regulated by the phosphorylation of its light and heavy chains. The three mammalian NM II isoforms have both overlapping and unique properties. Owing to its position downstream of convergent signalling pathways, NM II is central in the control of cell adhesion, cell migration and tissue architecture. Recent insight into the role of NM II in these processes has been gained from loss-of-function and mutant approaches, methods that quantitatively measure actin and adhesion dynamics and the discovery of NM II mutations that cause monogenic diseases.

Indexed as

AnimalsCell AdhesionCell MovementHumansMyosin Type IIMyosin Type II

Identifiers

PMID19851336
PMCPMC2834236
OpenAlexW2030029307

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.