ArticleObesity (Silver Spring, Md.)2010
Hypothalamic paraventricular nucleus lesion involvement in the sympathetic control of lipid mobilization.
Article in Obesity (Silver Spring, Md.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- From diet to hypothalamic dysfunction: Neuroanatomical and hormonal integration of the microbiota-hypothalamus-adipose tissue axis.Reviews in endocrine & metabolic disorders · 2026Review
- A Review onEndocrine, metabolic & immune disorders drug targets · 2025Review
- Metabolic and behavioral alterations associated with viral vector-mediated toxicity in the paraventricular hypothalamic nucleus.Bioscience reports · 2024Article
- Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease.Frontiers in endocrinology · 2024Review
- Modulation of the thermosensory system by oxytocin.Frontiers in molecular neuroscience · 2022Review
- Sympathetic Innervation of White Adipose Tissue: to Beige or Not to Beige?Physiology (Bethesda, Md.) · 2021Article
- Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease.Cell & bioscience · 2020Review
- Sensory denervation of inguinal white fat modifies sympathetic outflow to white and brown fat in Siberian hamsters.Physiology & behavior · 2018Article
- Mechanisms for AgRP neuron-mediated regulation of appetitive behaviors in rodents.Physiology & behavior · 2018Review
- Neonatal GLP1R activation limits adult adiposity by durably altering hypothalamic architecture.Molecular metabolism · 2017Article
- Deletion of p22JCI insight · 2017Article
- Molecular regulation of hypothalamic development and physiological functions.Molecular neurobiology · 2016Review
- Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism.Experimental & molecular medicine · 2016Review
- Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Neural innervation of white adipose tissue and the control of lipolysis.Frontiers in neuroendocrinology · 2014Review
- Short and long sympathetic-sensory feedback loops in white fat.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Molecular mechanisms of appetite regulation.Diabetes & metabolism journal · 2012Article
- Germline ablation of VGF increases lipolysis in white adipose tissue.The Journal of endocrinology · 2012Article
- Brain-gut-adipose-tissue communication pathways at a glance.Disease models & mechanisms · 2012Review
- Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure.PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The sympathetic nervous system (SNS) innervation of white adipose tissue (WAT) is the principal initiator of lipolysis. Using pseudorabies virus, a transneuronal viral tract tracer, brain sites involved in the SNS outflow to WAT have been identified previously by us. One of these sites, the hypothalamic paraventricular nucleus (PVH) that shows predominantly unilateral sympathetic outflow from each half of the nucleus to ipsilaterally located WAT depots, was tested for laterality in lipid accumulation/mobilization in Siberian hamsters. First we tested whether unilateral PVH electrolytic lesions (PVHx) would increase lipid accumulation in WAT pads ipsilateral to the side of the PVHx. PVHx significantly increased body and WAT pad masses compared with sham PVHx; however, there was no laterality effect. In addition, bilateral PVHx increased body and WAT pad masses, as well as food intake, to a greater extent than did unilateral PVHx. We next tested for possible laterality effects on WAT lipid mobilization using food deprivation as the lipolytic stimulus in hamsters bearing unilateral or bilateral PVHx. Lipid mobilization was not prevented, as indicated indirectly by WAT mass and thus laterality of lipid mobilization could not be tested. We then tested whether removal of adrenal catecholamines via adrenal demedullation (ADMEDx) alone, or combined with bilateral PVHx, would block food deprivation-induced lipid mobilization, but neither did so. These results suggest that an intact PVH is not necessary for food deprivation-induced lipid mobilization and support the primacy of the SNS innervation of WAT, rather than adrenal medullary catecholamines, for lipid mobilization from WAT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.