ArticleThe EMBO journal2010
Self-regulation of Stat3 activity coordinates cell-cycle progression and neural crest specification.
Article in The EMBO journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Is high-risk neuroblastoma induction chemotherapy possible without G-CSF? A pilot study of safety and treatment delays in the absence of primary prophylactic hematopoietic growth factors.Pediatric blood & cancer · 2020Trial
- FGF receptor modulates planar cell polarity in the neuroectoderm via Vangl2 tyrosine phosphorylation.Nature communications · 2025Article
- Immune escape and metastasis mechanisms in melanoma: breaking down the dichotomy.Frontiers in immunology · 2024Review
- Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting.World journal of stem cells · 2021Review
- Innate and Adaptive Immunity Linked to Recognition of Antigens Shared by Neural Crest-Derived Tumors.Cancers · 2020Review
- The regulatory proteins DSCR6 and Ezh2 oppositely regulate Stat3 transcriptional activity in mesoderm patterning duringThe Journal of biological chemistry · 2020Article
- Review
- Article
- Neuroblastoma pathogenesis: deregulation of embryonic neural crest development.Cell and tissue research · 2018Review
- Article
- Lapatinib Inhibits Breast Cancer Cell Proliferation by Influencing PKM2 Expression.Technology in cancer research & treatment · 2018Article
- Overexpression of DNMT3b target genes during Enteric Nervous System development contribute to the onset of Hirschsprung disease.Scientific reports · 2017Article
- Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea.Stem cell reports · 2017Article
- JAK-STAT pathway activation in response to spinal cord injury in regenerative and non-regenerative stages ofRegeneration (Oxford, England) · 2017Article
- Identification of different mechanisms leading to PAX6 down-regulation as potential events contributing to the onset of Hirschsprung disease.Scientific reports · 2016Article
- The Proto-oncogene Transcription Factor Ets1 Regulates Neural Crest Development through Histone Deacetylase 1 to Mediate Output of Bone Morphogenetic Protein Signaling.The Journal of biological chemistry · 2015Article
- G-CSF Promotes Neuroblastoma Tumorigenicity and Metastasis via STAT3-Dependent Cancer Stem Cell Activation.Cancer research · 2015Article
- TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation.Oncotarget · 2015Article
- STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion.The Journal of clinical investigation · 2015Article
- LIF-JAK1-STAT3 signaling delays contact inhibition of human corneal endothelial cells.Cell cycle (Georgetown, Tex.) · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A complex set of extracellular signals is required for neural crest (NC) specification. However, how these signals function to coordinate cell-cycle progression and differentiation remains poorly understood. Here, we report in Xenopus a role for the transcription factor signal transducers and activators of transcription-3 (Stat3) in this process downstream of FGF signalling. Depletion of Stat3 inhibits NC gene expression and cell proliferation, whereas overexpression expands the NC domain and promotes cell proliferation. Stat3 is phosphorylated and activated in ectodermal cells by FGFs through binding with FGFR4. Stat3 activation is also modulated by Hairy2 and Id3 proteins that, respectively, facilitate and disrupt Stat3-FGFR4 complex formation. Furthermore, distinct levels of Stat3 activity control Hairy2 and Id3 transcription, leading to Stat3 self-regulation. Finally, high Stat3 activity maintains cells in an undifferentiated state, whereas low activity promotes cell proliferation and NC differentiation. Together, our data suggest that Stat3, downstream of FGFs and under the positive and negative feedback regulation of Hairy2 and Id3, plays an essential role in the coordination of cell-cycle progression and differentiation during NC specification.
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