ArticleThe Journal of clinical investigation1991
Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.
Article in The Journal of clinical investigation, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 186 citations in OpenAlex.
- Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.The Journal of clinical investigation · 1996Trial
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- Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions.Scientific reports · 2021Article
- Perturbed Biochemical Pathways and Associated Oxidative Stress Lead to Vascular Dysfunctions in Diabetic Retinopathy.Oxidative medicine and cellular longevity · 2019Review
- Diabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C-peptide, sirtuin 1-liver kinase B1-adenosine monophosphate-activated protein kinase positive feedback and forkhead box O3.Journal of diabetes investigation · 2016Review
- Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes.World journal of diabetes · 2015Review
- Inhibition of PKC-θ preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy.British journal of pharmacology · 2014Article
- The effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy.International journal of clinical and experimental medicine · 2013Article
- Is fluid overload more important than diabetes in renal progression in late chronic kidney disease?PloS one · 2013Article
- Hyperglycemia and endothelial dysfunction in atherosclerosis: lessons from type 1 diabetes.International journal of vascular medicine · 2012Article
- Update on the management of diabetic polyneuropathies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2011Article
- Aortic vasoreactivity during a postnatal critical window of the pancreas in rats.Heart and vessels · 2010Article
- Activation of protein kinase C isoforms and its impact on diabetic complications.Circulation research · 2010Review
- Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation.Antioxidants & redox signaling · 2010Article
- Article
- Effects of protein kinase C inhibition and activation on proliferation and apoptosis of bovine retinal pericytes.Diabetologia · 2003Article
- Fatty acids inhibit growth-factor-induced diacylglycerol kinase alpha activation in vascular smooth-muscle cells.The Biochemical journal · 2001Article
- Article
- Regulators of vascular permeability: potential sites for intervention in the treatment of macular edema.Documenta ophthalmologica. Advances in ophthalmology · 1999Review
- Glucose-specific regulation of aldose reductase in capan-1 human pancreatic duct cells In vitro.The Journal of clinical investigation · 1997Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The present experiments were undertaken to examine the hypothesis that glucose-induced increased de novo synthesis of 1,2-diacyl-sn-glycerol (which has been observed in a number of different tissues, including retinal capillary endothelial cells exposed to elevated glucose levels in vitro) and associated activation of protein kinase C may play a role in mediating glucose-induced vascular functional changes. We report here that twice daily instillation of 30 mM glucose over 10 d in a rat skin chamber granulation tissue model induces approximately a 2.7-fold increase in diacylglycerol (DAG) levels (versus tissues exposed to 5 mM glucose) in association with marked increases in vascular clearance of albumin and blood flow. The glucose-induced increase in DAG levels as well as the vascular functional changes are prevented by addition of 3 mM pyruvate. Pharmacological activation of protein kinase C with the phorbol ester TPA in the presence of 5 mM glucose increases microvascular albumin clearance and blood flow, and similar effects are observed with 1-monoolein (MOG), a pharmacological inhibitor of the catabolism of endogenous DAG. A pharmacological inhibitor of protein kinase C (staurosporine) greatly attenuates the rise in microvascular albumin clearance (but not the rise in blood flow) induced by glucose or by MOG. These findings are compatible with the hypothesis that elevated concentrations of glucose increase tissue DAG content via de novo synthesis, resulting in protein kinase C activation, and that these biochemical events are among the factors that generate the increased microvascular albumin clearance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.