ArticleNucleic acids research2010
Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Canonical and extra-telomeric functions of telomerase: Implications for healthy ageing conferred by endurance training.Aging cell · 2023Review
- Exploring the Interplay of Telomerase Reverse Transcriptase and β-Catenin in Hepatocellular Carcinoma.Cancers · 2021Review
- Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms.Scientific reports · 2019Article
- Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics.International journal of molecular sciences · 2019Review
- Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema.Science translational medicine · 2016Article
- Telomerase: The Devil Inside.Genes · 2016Review
- Transcriptional outcome of telomere signalling.Nature reviews. Genetics · 2014Review
- Telomeres, a busy platform for cell signaling.Frontiers in oncology · 2013Article
- Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes.Journal of animal science and biotechnology · 2012Article
- Human telomerase reverse transcriptase (hTERT) is a target gene of β-catenin in human colorectal tumors.Cell cycle (Georgetown, Tex.) · 2012Article
- Axis of ageing: telomeres, p53 and mitochondria.Nature reviews. Molecular cell biology · 2012Review
- Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans.The EMBO journal · 2012Article
- Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis.Cell reports · 2012Article
- Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria.Frontiers in oncology · 2012Article
- Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.Molecular and cellular biology · 2011Article
- Dyskeratosis congenita and the DNA damage response.British journal of haematology · 2011Article
- Telomerase reverse transcriptase and Wnt signaling.Molecular and cellular biology · 2011Article
- Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins.Nature reviews. Cancer · 2011Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Telomerase, the essential enzyme that maintains telomere length, contains two core components, TERT and TR. Early studies in yeast and mouse showed that loss of telomerase leads to phenotypes only after several generations, due to telomere shortening. However, recent studies have suggested additional roles for telomerase components in transcription and the response to DNA damage. To examine these potential telomere length maintenance-independent roles of telomerase components, we examined first generation mTR(-/-) and mTERT(-/-) mice with long telomeres. We used gene expression profiling and found no genes that were differentially expressed in mTR(-/-) G1 mice and mTERT(-/-) G1 mice compared with wild-type mice. We also compared the response to DNA damage in mTR(-/-)G1 and mTERT(-/-) G1 mouse embryonic fibroblasts, and found no increase in the response to DNA damage in the absence of either telomerase component compared to wild-type. We conclude that, under physiologic conditions, neither mTR nor mTERT acts as a transcription factor or plays a role in the DNA damage response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.