Evidence map›Paper›PMID 19850147›Full record

ReviewThe international journal of biochemistry & cell biology2010

Fibrocytes: bringing new insights into mechanisms of inflammation and fibrosis.

Ellen C Keeley, Borna Mehrad, Robert M Strieter

Abstract readReview
In one paragraph

Review in The international journal of biochemistry & cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Trial
  2. Review
  3. Circulating Fibrocytes: Cellular Mediators of Tissue Fibrosis.International journal of molecular sciences · 2026
    Review
  4. Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Fibrocyte accumulation in the lungs of cystic fibrosis patients.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2020
    Article
  12. Article
  13. Article
  14. Infiltrating CCR2Scientific reports · 2019
    Article
  15. Review
  16. Significance of Intratumoral Fibrosis in Clear Cell Renal Cell Carcinoma.Journal of pathology and translational medicine · 2018
    Article
  17. Article
  18. Effect of Losartan on Mitral Valve Changes After Myocardial Infarction.Journal of the American College of Cardiology · 2017
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ellen C KeeleyDepartment of Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA 22908-0466, United States.
Borna Mehrad
Robert M Strieter

Funding

UVA Digestive Health Research CenterP30DK067629 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COHN, STEVEN M · 2004 to 2008
$5.6M
CXC Chemokines in CancerR01CA087879 · NCI · UNIVERSITY OF VIRGINIA · PI STRIETER, ROBERT M · 2000 to 2010
$3.4M
NK cells in host defense against invasive aspergillosisR01HL073848 · NHLBI · UNIVERSITY OF VIRGINIA · PI MEHRAD, BORNA · 2003 to 2013
$3.3M
Chemokines and Fibrocytes in Acute Lung InjuryR01HL066027 · NHLBI · UNIVERSITY OF VIRGINIA · PI STRIETER, ROBERT M · 2001 to 2009
$3.2M
Chemokines and Neovascularization in Coronary Artery DiseaseK23HL097074 · NHLBI · UNIVERSITY OF VIRGINIA · PI KEELEY, ELLEN CATHERINE · 2009 to 2013
$676k
NCI NIH HHS R01 CA087879NHLBI NIH HHS K23 HL097074NHLBI NIH HHS R01 HL066027NHLBI NIH HHS R01 HL073848NIDDK NIH HHS P30 DK067629
6 · The paper itself

Abstract

Regeneration and fibrosis are integral parts of the recovery process following tissue injury, and impaired regulation of these mechanisms is a hallmark of many chronic diseases. A population of bone marrow-derived mesenchymal progenitor cells known as fibrocytes, play an important role in tissue remodeling and fibrosis in both physiologic and pathologic settings. In this review we summarize the key concepts regarding the pathophysiology of wound healing and fibrosis, and present data to support the contention that circulating fibrocytes are important in both normal repair process and aberrant healing and fibrotic damage associated with a diverse set of disease states.

Indexed as

InflammationWound HealingAnimalsAntigens, CD34Bone MarrowCell DifferentiationFibrosisHumansMesenchymal Stem CellsRegenerationAntigens, CD34

Identifiers

PMID19850147
PMCPMC2835833

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.